Visible-light-induced cascade chromone cyclization/chalcogenation to access 3-chalcogenyl-chromones using elemental sulfur/selenium

Tao Guo; Chuanhu Gao; Zhonghui Li; Penghua Hu; Huan Chen; Shulei Han; Yunhui Zhao; Congjun Zhu

doi:10.1039/d4cc04609a

Visible-light-induced cascade chromone cyclization/chalcogenation to access 3-chalcogenyl-chromones using elemental sulfur/selenium

Chem Commun (Camb). 2024 Nov 26. doi: 10.1039/d4cc04609a. Online ahead of print.

Authors

Tao Guo¹, Chuanhu Gao¹, Zhonghui Li¹, Penghua Hu¹, Huan Chen², Shulei Han², Yunhui Zhao³, Congjun Zhu¹

Affiliations

¹ School of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou, Henan 450001, P. R. China.
² China National Tobacco Quality Supervision and Test Center, Key Laboratory of Tobacco Biological Effects, Zhengzhou, 450001, P. R. China.
³ School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, Hunan 411201, P. R. China.

PMID: 39588611
DOI: 10.1039/d4cc04609a

Abstract

A mild and efficient visible-light-induced cascade undergoing a chromone cyclization/chalcogenation at room temperature has been developed. This three-component reaction employs user-friendly elemental S₈ and Se as the chalcogenide source, providing an attractive route for the convenient synthesis of 3-chalcogenyl-chromones with a wide substrate scope and good functional group tolerance.