Base-promoted cascade 5- exo-dig annulation/carboxylation of o-(1-alkynyl)benzenesulfonamides with CO2: divergent synthesis of mono- or gem-dicarboxylic esters

Chem Commun (Camb). 2024 Nov 25. doi: 10.1039/d4cc05239k. Online ahead of print.

Abstract

A base-promoted cascade 5-exo-dig cyclization/carboxylation of o-alkynylsulfamides with CO2 has been accomplished, furnishing a variety of benzosultam-containing acrylates in good yields by using CO2 as the carboxylic source. Notably, in the case of substrates bearing a TMS-alkyne motif, the gem-dicarboxylation products were generated unprecedentedly.