Unleashing the therapeutic power of verteporfin-eluting stents: modulating YAP signaling to combat carotid artery restenosis and cerebral watershed infarction

Peng Zhang; Chenyang Xu; Zhijun Liu; Yadong Geng; Honglin Liu

doi:10.1007/s11010-024-05160-4

Unleashing the therapeutic power of verteporfin-eluting stents: modulating YAP signaling to combat carotid artery restenosis and cerebral watershed infarction

Mol Cell Biochem. 2024 Nov 22. doi: 10.1007/s11010-024-05160-4. Online ahead of print.

Authors

Peng Zhang¹, Chenyang Xu¹, Zhijun Liu¹, Yadong Geng¹, Honglin Liu²

Affiliations

¹ Department of Neurosurgery, Huaihe Hospital of Henan University, No.1, Baogonghubei Road, Gulou District, Kaifeng, 475000, Henan Province, China.
² Department of Neurosurgery, Huaihe Hospital of Henan University, No.1, Baogonghubei Road, Gulou District, Kaifeng, 475000, Henan Province, China. 369879164@qq.com.

PMID: 39576466
DOI: 10.1007/s11010-024-05160-4

Abstract

Carotid artery stenosis is the main cause of cerebral watershed infarction (CWI). In recent years, increasing attention has been given to treating this condition. The present study aimed to investigate how Verteporfin-eluting stent (VPES) modulates the YAP signaling pathway to inhibit restenosis of the carotid artery and alleviate CWI. Through transcriptome sequencing and functional experiments, it was found that VP could regulate the Yes-associated protein (YAP) signaling pathway and effectively suppress the proliferation and migration of smooth muscle cells (SMCs). Further investigation revealed that VPES could inhibit carotid artery restenosis through the YAP signaling pathway in a rabbit model, reducing the occurrence of CWI.

Keywords: Carotid artery restenosis; Cerebral watershed infarction; Smooth muscle cells; Transcriptome sequencing; Verteporfin-eluting stent; YAP signaling pathway.