Prenatal Silicon Dioxide Nanoparticles Exposure Reduces Female Offspring Fertility Without Affecting Males

Min Lei; Zhenye Zhu; Chenlu Wei; Huihui Xie; Ruizhi Guo; Yanqing Zhao; Keer Wang; Mengchen Wang; Wenhui Chen; Xiqiao Xu; Xinxin Zeng; Yining Xu; Wandi Zhang; Yizhe Chu; Yingpu Sun; Qingling Yang

doi:10.1002/advs.202410353

Prenatal Silicon Dioxide Nanoparticles Exposure Reduces Female Offspring Fertility Without Affecting Males

Adv Sci (Weinh). 2024 Nov 22:e2410353. doi: 10.1002/advs.202410353. Online ahead of print.

Authors

Min Lei^{1

2

3}, Zhenye Zhu^{1

2

3}, Chenlu Wei^{1

2

3}, Huihui Xie^{1

2

3}, Ruizhi Guo^{1

2

3}, Yanqing Zhao^{1

2

3}, Keer Wang^{1

2

3}, Mengchen Wang^{1

2

3}, Wenhui Chen^{1

2

3}, Xiqiao Xu^{1

2

3}, Xinxin Zeng^{1

2

3}, Yining Xu^{1

2

3}, Wandi Zhang^{1

2

3}, Yizhe Chu^{1

2

3}, Yingpu Sun^{1

2

3}, Qingling Yang^{1

2

3}

Affiliations

¹ Center for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
² Henan Key Laboratory of Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
³ Henan Provincial Obstetrical and Gynecological Diseases (Reproductive Medicine) Clinical Research Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.

PMID: 39574356
DOI: 10.1002/advs.202410353

Abstract

Silicon dioxide nanoparticles (SiO₂ NPs) are widely utilized in biomedicine due to their controllable size and biocompatibility. While previous studies have demonstrated that prenatal exposure to SiO₂ NPs can traverse the placental barrier and induce neurotoxicity in offspring. However, their reproductive toxicity remains unclear. Here, it is found that prenatal SiO₂ NPs exposure led to subfertility in female offspring, evidenced by decreased ovulation potential, ovarian reserve, and litter size. In contrast, male offspring maintained normal sperm production and fertility. Mechanistic analyses revealed that prenatal SiO₂ NPs exposure disrupted meiotic recombination and increased oocyte apoptosis, resulting in reduced postnatal primordial follicle formation in females. Conversely, meiotic recombination occurring postnatally in male offspring remained unaffected. Notably, treatment with carboxylate (COOH)-functionalized SiO₂ nanoparticles (SiO₂-COOH NPs) has a minimal impact on fertility in female offspring. Further research, including clinical studies, is needed to confirm these findings in humans. These findings demonstrated gender-specific reproductive toxicity induced by prenatal SiO₂ NPs exposure and highlighted the importance of considering nanoparticle safety in prenatal contexts.

Keywords: meiosis; oocyte; prenatal exposure; reproductive toxicity; silicon dioxide nanoparticles; testis.

Abstract

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