Chronological Changes in Embolization for Cerebral Arteriovenous Malformations: Impact of Endovascular Treatment Device Advancements

Yoshiro Ito; Yuji Matsumaru; Hisayuki Hosoo; Shun Tanaka; Kota Araki; Sho Okune; Koji Hirata; Aiki Marushima; Mikito Hayakawa; Eiichi Ishikawa

doi:10.5797/jnet.oa.2024-0041

Chronological Changes in Embolization for Cerebral Arteriovenous Malformations: Impact of Endovascular Treatment Device Advancements

J Neuroendovasc Ther. 2024;18(11):279-286. doi: 10.5797/jnet.oa.2024-0041. Epub 2024 Sep 14.

Authors

Yoshiro Ito^{1

2}, Yuji Matsumaru^{1

2}, Hisayuki Hosoo^{1

2}, Shun Tanaka², Kota Araki^{1

2}, Sho Okune², Koji Hirata^{1

2}, Aiki Marushima^{1

2}, Mikito Hayakawa², Eiichi Ishikawa¹

Affiliations

¹ Department of Neurosurgery, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
² Department of Stroke and Cerebrovascular Diseases, University of Tsukuba Hospital, Tsukuba, Ibaraki, Japan.

Abstract

Objective: Although embolization of cerebral arteriovenous malformations (AVM) is widely performed as an adjunctive therapy before microsurgery or radiosurgery, there is no high-level evidence to ascertain its effectiveness. However, the technology for endovascular devices has improved. Therefore, this study aimed to identify the chronological changes in AVM embolization due to advances in endovascular treatment devices.

Methods: This retrospective study included 24 patients who underwent 31 embolization procedures between January 2018 and August 2023. Embolization plus microsurgery, embolization plus radiosurgery, and embolization alone were performed in 15 (62.5%) patients and 21 embolization procedures, 2 (8.3%) patients and 2 procedures, and 7 (29.2%) patients and 8 procedures, respectively. We assessed chronological changes in endovascular treatment devices and evaluated clinical outcomes (ideal position of microcatheter, vessel perforations, symptomatic complications) from January 2018 to December 2020 and from January 2021 to August 2023 based on the chronological changes in endovascular treatment devices.

Results: Intermediate catheters were employed in 29 (93.5%) procedures. Brands of intermediate catheters and microcatheters significantly changed around 2021. No differences were observed in the embolic materials. The ideal position of the microcatheter was achieved significantly more in 2021-2023 than in 2018-2020 (72.1% vs. 48.4%, p = 0.04). Vessel perforation by microcatheters in 2018-2020 and 2021-2023 occurred in 3 (18.8%) and 1 (6.7%) procedures (p = 0.32), respectively. Symptomatic complications in 2018-2020 and 2021-2023 occurred in 3 (18.8%) and 0 (p = 0.08) procedures, respectively. Complete obliteration was achieved in 18 of 24 patients (75.0%). Favorable clinical outcomes (modified Rankin Scale score 0-2) were observed in 20 of 24 (83.3%) patients at the final follow-up.

Conclusion: The advancement in endovascular devices for AVM has enabled effective and safe embolization, potentially enhancing the outcomes of microsurgical interventions.

Keywords: arteriovenous malformation; chronological change; endovascular device; intermediate catheter; microcatheter.