Staphylococcus epidermidis alters macrophage polarization and phagocytic uptake by extracellular DNA release in vitro

NPJ Biofilms Microbiomes. 2024 Nov 20;10(1):131. doi: 10.1038/s41522-024-00604-7.

Abstract

Biofilm formation shields Staphylococcus epidermidis from host defense mechanisms, contributing to chronic implant infections. Using wild-type S. epidermidis 1457, a PIA-negative mutant (1457-M10), and an eDNA-negative mutant (1457ΔatlE), this study examined the influence of biofilm matrix components on human monocyte-derived macrophage (hMDM) interactions. The wild-type strain was resistant to phagocytosis and induced an anti-inflammatory response in hMDMs, while both mutants were more susceptible to phagocytosis and triggered a pro-inflammatory response. Removing eDNA from the 1457 biofilm matrix increased hMDM uptake and a pro-inflammatory reaction, whereas adding eDNA to the 1457ΔatlE mutant reduced phagocytosis and promoted an anti-inflammatory response. Inhibiting TLR9 enhanced bacterial uptake and induced a pro-inflammatory response in hMDMs exposed to wild-type S. epidermidis. This study highlights the critical role of eDNA in immune evasion and the central role of TLR9 in modulating macrophage responses, advancing the understanding of implant infections.

MeSH terms

  • Biofilms* / growth & development
  • DNA, Bacterial* / genetics
  • Humans
  • Immune Evasion
  • Macrophages* / immunology
  • Macrophages* / metabolism
  • Macrophages* / microbiology
  • Phagocytosis*
  • Staphylococcal Infections / immunology
  • Staphylococcal Infections / microbiology
  • Staphylococcus epidermidis* / genetics
  • Staphylococcus epidermidis* / physiology
  • Toll-Like Receptor 9* / metabolism

Substances

  • Toll-Like Receptor 9
  • DNA, Bacterial
  • TLR9 protein, human