Calcium Balance through Mutual Orchestrated Inter-organelle Communication: A Pleiotropic Target for Combating Alzheimer's Disease

Muhammad Kamal Hossain; Han Jung Chae

doi:10.1016/j.neuint.2024.105905

Calcium Balance through Mutual Orchestrated Inter-organelle Communication: A Pleiotropic Target for Combating Alzheimer's Disease

Neurochem Int. 2024 Nov 18:105905. doi: 10.1016/j.neuint.2024.105905. Online ahead of print.

Authors

Muhammad Kamal Hossain¹, Han Jung Chae²

Affiliations

¹ School of Pharmacy, Jeonbuk National University, Jeonju 54896, Republic of Korea.
² School of Pharmacy, Jeonbuk National University, Jeonju 54896, Republic of Korea. Electronic address: hjchae@jbnu.ac.kr.

PMID: 39566580
DOI: 10.1016/j.neuint.2024.105905

Abstract

Dysfunctional intraneuronal organelles in Alzheimer's Disease (AD) propel aberrant calcium handling, triggering molecular miscommunication within organelles such as mitochondria, endoplasmic reticulum, and lysosomes. This disruption in organelle function not only impairs cellular homeostasis but also exacerbates neurodegenerative processes involving the accumulation of amyloid-β (Aβ) and hyperphosphorylated tau, amplifying the disease's vicious cycle. In this review, the concept of Mutual Orchestrated Inter-organelle Communication (MOIC) proposes potential therapeutic avenues for restoring Ca²⁺ homeostasis in AD, offering a theoretical framework for developing disease-modifying treatments. The intricate nature of AD necessitates a shift towards combination therapies targeting MOIC-associated pathways, presenting a more effective approach than monotherapy.

Keywords: Alzheimer's disease; Ca(2+) homeostasis; Intraneuronal organelles; MOIC.

Publication types

Review