Microbial degradation mechanisms of the neonicotinoids acetamiprid and flonicamid and the associated toxicity assessments

Shilei Sun; Jingjing Guo; Zhi Zhu; Jiangsheng Zhou

doi:10.3389/fmicb.2024.1500401

Microbial degradation mechanisms of the neonicotinoids acetamiprid and flonicamid and the associated toxicity assessments

Front Microbiol. 2024 Nov 5:15:1500401. doi: 10.3389/fmicb.2024.1500401. eCollection 2024.

Authors

Shilei Sun^#¹, Jingjing Guo^#², Zhi Zhu¹, Jiangsheng Zhou¹

Affiliations

¹ The Key Laboratory of Biotechnology for Medicinal Plants of Jiangsu Province and School of Life Science, Jiangsu Normal University, Xuzhou, China.
² School of Life Science and Environmental Engineering, Nanjing Normal University Zhongbei College, Zhenjiang, China.

^# Contributed equally.

Abstract

Extensive use of the neonicotinoid insecticides acetamiprid (ACE) and flonicamid (FLO) in agriculture poses severe environmental and ecological risks. Microbial remediation is considered a feasible approach to address these issues. Many ACE-and FLO-degrading microorganisms have been isolated and characterized, but few reviews have concentrated on the underlying degradation mechanisms. In this review, we describe the microbial degradation pathways of ACE and FLO and assess the toxicity of ACE, FLO and their metabolites. Especially, we focus on the enzymes involved in degradation of ACE and FLO, including cytochrome P450s, nitrile hydratases, amidases, and nitrilases. Those studies reviewed here further our understanding of the enzymatic mechanisms of microbial degradation of ACE and FLO, and aid in the application of microbes to remediate environmental ACE and FLO contamination.

Keywords: acetamiprid; biodegradation; flonicamid; molecular mechanism; neonicotinoid insecticide.

Publication types

Review

Grants and funding

The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This research was financed by the National Natural Science Foundation of China (grant number 32000063) and Natural Science Foundation of Jiangsu Normal University (grant number 19XSRS006).