Faecal phageome transplantation alleviates intermittent intestinal inflammation in IBD and the timing of transplantation matters: a preclinical proof-of-concept study in mice

Gut. 2024 Nov 19:gutjnl-2024-333598. doi: 10.1136/gutjnl-2024-333598. Online ahead of print.

Nengneng Li^{1

2

3}, Yue Li^{1

2

3}, Ziyu Huang^{1

2

3}, Zhirui Cao^{1

2}, Cha Cao⁴, Xiang Gao^{2

5}, Tao Zuo^{6

2

3

7}

¹ Key Laboratory of Human Microbiome and Chronic Diseases, Ministry of Education, Sun Yat-Sen University, Guangzhou, Guangdong, China.
² Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangdong Institute of Gastroenterology, The Sixth Affiliated Hospital of Sun Yat-sen University, Sun Yat-sen University, Guangzhou, Guangdong, China.
³ Centre for Fecal Microbiota Transplantation Research, The Sixth Affiliated Hospital of Sun Yat-sen University, Sun Yat-sen University, Guangzhou, Guangdong, China.
⁴ College of Life Science and Technology, Department of Food Science and Engineering, Jinan University, Guangzhou, Guangdong, China.
⁵ Department of Gastroenterology, The Sixth Affiliated Hospital of Sun Yat-sen University, Sun Yat-sen University, Guangzhou, Guangdong, China.
⁶ Key Laboratory of Human Microbiome and Chronic Diseases, Ministry of Education, Sun Yat-Sen University, Guangzhou, Guangdong, China zuot@mail.sysu.edu.cn.
⁷ Biomedical Innovation Center, The Sixth Affiliated Hospital of Sun Yat-sen University, Sun Yat-sen University, Guangzhou, Guangdong, China.

No abstract available

Keywords: gut inflammation; inflammatory bowel disease; intestinal microbiology.

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