Alzheimer's disease (AD) is the most common type of dementia. Studies have shown that neuronal cell cycle re-entry is an abnormal change in the early stage of AD, and it is also one of the key reasons for mediating neuronal death. The mechanism of acupuncture and moxibustion in treating AD may be related to the regulation of abnormal cell cycle. In this article, we reviewed the occurrence of AD neuronal cell cycle re-entry and its mediated cell death mechanism, listed the factors affecting neuronal cell cycle re-entry, explored the possible mechanism of acupuncture and moxibustion in preventing and treating AD by regulating AD cell cycle protein, AD neuronal cell cycle re-entry influencing factors (β-amyloid protein and Tau protein phosphorylation level, oxidative stress, brain-derived neurotrophic factor), the multi-target regulation of neuronal cell cycle re-entry, so as to provide reference for the application and research of acupuncture and moxibustion in preventing and treating AD.
阿尔茨海默病（AD）是最常见的痴呆类型。研究表明，神经元细胞周期重启是AD早期的异常改变，也是介导神经元死亡的关键原因之一，而针灸治疗AD的作用机制可能与调控神经元异常细胞周期有关。本文对AD神经元细胞周期重启的发生及其介导的细胞死亡机制进行综述，列举了影响神经元细胞周期重启的因素，探讨针灸通过调节AD细胞周期蛋白、AD神经元细胞周期重启影响因素（β-淀粉样蛋白及Tau蛋白磷酸化水平、氧化应激、脑源性神经营养因子）多靶点调控神经元细胞周期重启防治AD的可能机制，以期为针灸防治AD的应用与研究提供参考。.
Keywords: Acupuncture; Alzheimer’s disease; Cell cycle; Moxibustion; Neuron.