Pharmacokinetic and Pharmacodynamic Changes in the Older Adults: Impact on Anesthetics

Abstract

Anesthesiologists are increasingly required to care for frail older adults patients. A detailed knowledge of the influence of age on the pharmacokinetics and dynamics of the anesthetic drugs is essential for optimal safety and care. For most of the anesthetic drugs, the older adults need lower doses to achieve the same plasma concentrations, and at any given plasma and effect-site concentration, they will have more profound clinical effects than younger patients. Caution is required, with close monitoring of clinical effects and active titration of dose administration to achieve the desired level of effect, ideally following the "start low, go slow" principle.

Keywords: Aging; Frailty; Pharmacodynamics; Pharmacokinetics; Physiology; Senescence.