Antimicrobial GL13K Peptide-Decorated ZnO Nanoparticles To Treat Bacterial Infections

Xu Zhang; Yinghao Liu; Xue'e Zhang; Mengzhen Tang; Weihong Xi; Junchao Wei

doi:10.1021/acs.langmuir.4c03206

Antimicrobial GL13K Peptide-Decorated ZnO Nanoparticles To Treat Bacterial Infections

Langmuir. 2024 Nov 14. doi: 10.1021/acs.langmuir.4c03206. Online ahead of print.

Authors

Xu Zhang^{1

2

3}, Yinghao Liu^{1

3}, Xue'e Zhang^{1

2

3}, Mengzhen Tang^{1

2

3}, Weihong Xi^{1

2

3}, Junchao Wei^{1

2

3

4}

Affiliations

¹ School of Stomatology, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi 330006, People's Republic of China.
² Jiangxi Provincial Key Laboratory of Oral Diseases, Nanchang, Jiangxi 330006, People's Republic of China.
³ Jiangxi Provincial Clinical Research Center for Oral Diseases, Nanchang, Jiangxi 330006, People's Republic of China.
⁴ School of Chemistry and Chemical Engineering, Nanchang University, Nanchang, Jiangxi 330031, People's Republic of China.

PMID: 39540901
DOI: 10.1021/acs.langmuir.4c03206

Abstract

As a broad-spectrum antimicrobial material, ZnO nanoparticles (NPs) offer a novel approach to infected wounds in the clinic; however, it is very necessary to improve the antimicrobial performance of ZnO to satisfy the clinic requirements. In this work, a new antimicrobial hybrid ZnO@PDA/GL13K was prepared by attaching the antimicrobial GL13K peptide on the surface of ZnO NPs via polydopamine (PDA) as a covalent bonding agent, which can enhance the reactive oxygen species (ROS) production and damage the cell wall, showing superior antimicrobial efficacy. Besides, the ZnO@PDA/GL13K hybrid can promote the healing of bacterial infected wounds, with the wound area only remaining 1.8% on day 9, about 2 times smaller than that of the ZnO group. Moreover, ZnO@PDA/GL13K also showed good biocompatibility, and no side effect on normal tissue and organs was found, implying that the antimicrobial hybrid may possess prospective application in biomedical fields.