The Relationship Between Rim-like Enhancement on Pre-ablation Contrast-enhanced Ultrasound of Colorectal Liver Metastasis and Early Intrahepatic Progression After Thermal Ablation: A Preliminary Study

Jia Lin; Huahui Liu; Shuang Liang; Liping Luo; Sainan Guan; Shanshan Wu; Ying Liu; Shuxian Xu; Ronghua Yan; Erjiao Xu

doi:10.1016/j.ultrasmedbio.2024.10.015

The Relationship Between Rim-like Enhancement on Pre-ablation Contrast-enhanced Ultrasound of Colorectal Liver Metastasis and Early Intrahepatic Progression After Thermal Ablation: A Preliminary Study

Ultrasound Med Biol. 2024 Nov 12:S0301-5629(24)00411-3. doi: 10.1016/j.ultrasmedbio.2024.10.015. Online ahead of print.

Authors

Jia Lin¹, Huahui Liu¹, Shuang Liang¹, Liping Luo¹, Sainan Guan¹, Shanshan Wu¹, Ying Liu¹, Shuxian Xu¹, Ronghua Yan², Erjiao Xu³

Affiliations

¹ Department of Medical Ultrasonics, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong, China.
² Department of Radiology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China.
³ Department of Medical Ultrasonics, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong, China. Electronic address: xuerjiao@mail.sysu.edu.cn.

PMID: 39537546
DOI: 10.1016/j.ultrasmedbio.2024.10.015

Abstract

Objective: To investigate the relationship between the rim-like enhancement pattern on pre-ablation contrast-enhanced ultrasound (CEUS) of colorectal liver metastasis (CRLM) and the therapeutic efficacy of percutaneous microwave ablation (MWA).

Methods: Patients with CRLM underwent MWA and were evaluated using CEUS before ablation in our hospital between February 2020 and February 2023 were enrolled in this retrospective study. The enhancement patterns of CRLM were assessed by two radiologists and classified as rim-like enhancement and non-rim-like enhancement patterns. The therapeutic outcomes, including cumulative intrahepatic progression rate and early intrahepatic progression rate, were followed up and analyzed.

Results: Overall, 50 patients with 121 nodules were enrolled. Rim-like enhancement pattern was observed in 18 patients (18/50, 36.0%). The cumulative intrahepatic progression rate was significantly higher in the rim-like enhancement group than the rate in the non-rim-like enhancement group (p = 0.022). The early intrahepatic progression rate in the rim-like enhancement group was also significantly higher than the rate in the non-rim-like enhancement group (12/17, 70.6% vs. 6/24, 25.0%, p = 0.005). The multivariable analysis demonstrated that the rim-like enhancement pattern of CRLM was a significant risk factor associated with early intrahepatic progression after MWA (p = 0.013).

Conclusion: Rim-like enhancement pattern on pre-ablation CEUS of CRLM was associated with a higher risk of intrahepatic progression after MWA.

Keywords: Colorectal liver metastasis; Contrast-enhanced ultrasound; Early intrahepatic progression; Microwave ablation.