Per- and polyfluoroalkyl substances (PFASs) are a large group of anthropogenic fluorinated chemicals. Ultrashort-chain perfluoroalkyl acids (PFAAs) have recently gained attention due to their prevalence in the environment and increasing environmental concerns. In this review, we established a literature database from 1990 to 2024, encompassing environmental and biological concentrations (>3,500 concentration records) of five historically overlooked ultrashort-chain PFAAs (perfluoroalkyl carboxylic and sulfonic acids with less than 4 carbons): trifluoroacetic acid (TFA), perfluoropropanoic acid (PFPrA), trifluoromethanesulfonic acid (TFMS), perfluoroethanesulfonate (PFEtS), and perfluoropropanesulfonate (PFPrS). Our data mining and analysis reveal that (1) ultrashort-chain PFAAs are globally distributed in various environments including water bodies, solid matrices, and air, with concentrations usually higher than those of longer-chain compounds; (2) TFA, the most extensively studied ultrashort-chain PFAA, shows a consistent upward trend in concentrations in surface water, rainwater, and air over the past three decades; and (3) ultrashort-chain PFAAs are present in various organisms, including plants, wildlife, and human blood, serum, and urine, with concentrations sometimes similar to those of longer-chain compounds. The current state of knowledge regarding the sources and fate of TFA and other ultrashort-chain PFAAs is also reviewed. Amid the global urgency to regulate PFASs, particularly as countries worldwide have intensified such efforts, this critical review will inform scientific research and regulatory policies.
Keywords: Occurrence; PFASs; PFPrA; Temporal trends; Trifluoroacetic acid.