Aging and frailty are associated with inflammatory endotypic shifts in patients with chronic rhinosinusitis

Mason R Krysinski; Christina Dorismond; Yash Trivedi; Rory Lubner; Andrea A Lopez; Kolin Rubel; Rakesh K Chandra; Naweed I Chowdhury; Justin H Turner

doi:10.1002/alr.23484

Aging and frailty are associated with inflammatory endotypic shifts in patients with chronic rhinosinusitis

Int Forum Allergy Rhinol. 2024 Nov 13. doi: 10.1002/alr.23484. Online ahead of print.

Authors

Mason R Krysinski¹, Christina Dorismond¹, Yash Trivedi², Rory Lubner¹, Andrea A Lopez², Kolin Rubel³, Rakesh K Chandra¹, Naweed I Chowdhury¹, Justin H Turner^{1

4}

Affiliations

¹ Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
² Vanderbilt University School of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
³ Department of Otolaryngology-Head and Neck Surgery, University of Minnesota Medical Center, Nashville, Tennessee, USA.
⁴ Department of Otolaryngology, University of Alabama at Birmingham, Birmingham, Alabama, USA.

PMID: 39535331
DOI: 10.1002/alr.23484

Abstract

Frailty and aging are associated with a shift toward non-type 2 inflammation in chronic rhinosinusitis (CRS). Frailty-related shifts in sinonasal inflammatory mediators may be linked to biological senescence. Understanding the role of aging and frailty in CRS may have important treatment implications.

Keywords: aging; chronic rhinosinusitis; cytokine; endotype; frailty; immunosenescence.

Abstract

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