Kaposiform Hemangioendothelioma With Features of Congenital Hemangioma Treated With Sirolimus

Danny Lee; Jennifer Sui; Alreem Al-Nabti; Deborah Schiff; Catalina Matiz; John Naheedy; Dawn Z Eichenfield

doi:10.1111/pde.15782

Kaposiform Hemangioendothelioma With Features of Congenital Hemangioma Treated With Sirolimus

Pediatr Dermatol. 2024 Nov 11. doi: 10.1111/pde.15782. Online ahead of print.

Authors

Danny Lee¹, Jennifer Sui², Alreem Al-Nabti³, Deborah Schiff^{4

5}, Catalina Matiz⁶, John Naheedy⁷, Dawn Z Eichenfield^{1

2

8}

Affiliations

¹ University of California San Diego School of Medicine, La Jolla, California, USA.
² Department of Dermatology, University of California San Diego, La Jolla, California, USA.
³ Department of Dermatology, Weill Cornell Medicine, New York, New York, USA.
⁴ Department of Hematology-Oncology, Rady's Children Hospital, San Diego, California, USA.
⁵ Department of Pediatrics, University of California San Diego, La Jolla, California, USA.
⁶ Department of Dermatology, Kaiser Permanente San Diego, San Diego, California, USA.
⁷ Department of Radiology, Rady's Children Hospital, San Diego, California, USA.
⁸ Division of Adolescent and Pediatric Dermatology, Rady Children's Hospital, San Diego, California, USA.

PMID: 39528249
DOI: 10.1111/pde.15782

Abstract

Kaposiform hemangioendothelioma (KHE) is a vascular neoplasm characterized by abnormal angiogenesis and lymphangiogenesis. Here, we present a case of a 19-month-old male with KHE of the right leg with bony involvement who was initially misdiagnosed with infantile hemangioma. Due to its heterogeneous presentation and frequent occurrence of comorbidities such as Kasabach-Merritt phenomenon, clinical and pathological correlation is essential for diagnosis of KHE.

Keywords: Kasabach‐Merritt syndrome; hemangioendothelioma; hemangioma; sirolimus; vascular malformations.

Publication types

Letter