Respiratory Outcomes of Infants Born Extremely Preterm in the Necrotizing Enterocolitis Surgery Trial

Sara B DeMauro; Erik A Jensen; Scott A McDonald; Susan Hintz; Jon Tyson; David K Stevenson; Martin L Blakely; NICHD Neonatal Research Network. A complete list of study group members and their affiliations is provided in the Acknowledgments (online)

doi:10.1016/j.jpeds.2024.114391

Respiratory Outcomes of Infants Born Extremely Preterm in the Necrotizing Enterocolitis Surgery Trial

J Pediatr. 2024 Nov 7:114391. doi: 10.1016/j.jpeds.2024.114391. Online ahead of print.

Authors

Sara B DeMauro¹, Erik A Jensen², Scott A McDonald³, Susan Hintz⁴, Jon Tyson⁵, David K Stevenson⁴, Martin L Blakely⁵; NICHD Neonatal Research Network. A complete list of study group members and their affiliations is provided in the Acknowledgments (online)

Affiliations

¹ University of Pennsylvania Perelman School of Medicine. Electronic address: DeMauro@chop.edu.
² University of Pennsylvania Perelman School of Medicine.
³ RTI, International.
⁴ Stanford University School of Medicine.
⁵ University of Texas Health Science Center at Houston.

PMID: 39521175
DOI: 10.1016/j.jpeds.2024.114391

Abstract

The multicenter Necrotizing Enterocolitis Surgery Trial compared initial peritoneal drainage with laparotomy among infants with extremely low birth weight and surgical necrotizing enterocolitis or intestinal perforation. In this post hoc analysis of trial data, initial drainage was associated with adverse respiratory outcomes, both in hospital and through 2 years corrected age.