Is CAR T a drug or a therapeutic pathway? Intention to treat versus per protocol analysis of real world studies of CAR-T cell therapy in relapsed refractory diffuse large B cell lymphoma
Blood Cancer J. 2024 Nov 7;14(1):197.
doi: 10.1038/s41408-024-01183-8.
1 Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
2 IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia "Seràgnoli", Bologna, Italy.
3 Moffitt Cancer Center, Tampa, FL, USA.
4 Division of Hematology, The Ohio State University, Columbus, OH, USA.
5 Instituto de Investigación Sanitaria Gregorio Marañón, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
6 Unit of Lymphoma. Department of Hematology. Son Espases University Hospital (IdISBa), Palma de Mallorca, Spain.
7 Department of Hematology, Hospital Universitario de Salamanca, IBSAL, CIBERONC, Salamanca, Spain; University of Salamanca, Salamanca, Spain.
8 Servicio de Hematología y Oncología Médica, Hospital Clinico Universitario de Valencia, Valencia, Spain.
9 Department of Medicine/Division of Hematology and Oncology, UCLA Medical Center, Santa Monica, CA, USA.
10 Department of Medicine/Division of Hematology and Oncology, UCLA Medical Center, Los Angeles, CA, USA.
11 Department of Hematology, University Hospital Vall d'Hebron, Barcelona, Spain.
12 Universitat Autònoma de Barcelona, Bellaterra, Spain.
13 Department of Hematology, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Universidad Complutense de Madrid, Madrid, Spain.
14 Hospital Universitario Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS) / CSIC, Universidad de Sevilla, Seville, Spain.
15 Department of Hematology and Medical Oncology Taussig Cancer Institute Cleveland Clinic, Cleveland, OH, USA.
16 Centre Hospitalier Lyon-Sud, Pierre-Bénite, France.
17 Hematology Department, Centre Hospitalier Régional Universitaire de Lille, Lille, AL, France.
18 Department of Hematology, University Hospital of Rennes, UMR U1236, INSERM, University of Rennes, Rennes, France.
19 Hematology Department, Hôpital Saint-Louis, Paris, France.
20 Hematology Department, Institut Curie, Paris, France.
21 Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
22 Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy. lisa.argnani@unibo.it.