Surgical Management of Gynecologic Cancers

Hematol Oncol Clin North Am. 2025 Feb;39(1):67-87. doi: 10.1016/j.hoc.2024.08.013.

Abstract

This article addresses the role of surgery in the management of gynecologic cancers with liver metastases. The authors review the short-term and long-term outcomes of aggressive resection through retrospective and randomized studies. Although the data supporting aggressive resection of liver metastasis are largely retrospective and case based, the randomized control data to address neoadjuvant versus chemotherapy have been widely criticized. Residual disease remains an important predictor for survival in ovarian cancer. If a patient cannot achieve near optimal cytoreduction, radical cytoreductive procedures, such as hepatic resection, should be considered for palliation only.

Keywords: Cervical cancer with liver metastases; Metastatic gynecologic cancer; Ovarian; Stage IV uterine.

Publication types

  • Review

MeSH terms

  • Cytoreduction Surgical Procedures / methods
  • Disease Management
  • Female
  • Genital Neoplasms, Female* / pathology
  • Genital Neoplasms, Female* / surgery
  • Humans
  • Liver Neoplasms / mortality
  • Liver Neoplasms / pathology
  • Liver Neoplasms / secondary
  • Liver Neoplasms / surgery
  • Neoadjuvant Therapy
  • Ovarian Neoplasms / mortality
  • Ovarian Neoplasms / pathology
  • Ovarian Neoplasms / surgery