Cardio-metabolic Disorders Affected by Genetic Polymorphisms Related to Premature Menopause

Mohammad Reza Mirinezhad; Hamideh Safarian Bana; Maliheh Aghsizadeh; Mohammad Amin Mohammadi; Hamideh Ghazizadeh; Ali Ebrahimi Dabagh; Sayyedeh Helya Mir Nourbakhsh; Hassan Kiani Shahvandi; Alireza Ghodsi; Mahdie Aghsizadeh; Faezeh Taghipour; Elahe Hasanzadeh; Nazanin Sheikh Andalibi; Hamed Khedmatgozar; Gordon A Ferns; Tayebeh Hamzehloei; Alireza Pasdar; Majid Ghayour-Mobarhan

doi:10.2174/0118715257297949241023053739

Cardio-metabolic Disorders Affected by Genetic Polymorphisms Related to Premature Menopause

Cardiovasc Hematol Agents Med Chem. 2024 Nov 5. doi: 10.2174/0118715257297949241023053739. Online ahead of print.

Authors

Mohammad Reza Mirinezhad¹, Hamideh Safarian Bana², Maliheh Aghsizadeh², Mohammad Amin Mohammadi³, Hamideh Ghazizadeh³, Ali Ebrahimi Dabagh¹, Sayyedeh Helya Mir Nourbakhsh⁴, Hassan Kiani Shahvandi⁴, Alireza Ghodsi⁵, Mahdie Aghsizadeh², Faezeh Taghipour⁶, Elahe Hasanzadeh¹, Nazanin Sheikh Andalibi⁵, Hamed Khedmatgozar⁵, Gordon A Ferns⁷, Tayebeh Hamzehloei², Alireza Pasdar^{2

8

9}, Majid Ghayour-Mobarhan³

Affiliations

¹ Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
² Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.
³ International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.
⁴ Student Research Committee, Ahvaz Jondishapour University of Medical Sciences, Ahvaz, Iran.
⁵ Department of Nutrition Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran.
⁶ Mashhad University of Medical Sciences Student Research Committee Mashhad Iran.
⁷ Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, SussexBN1 9PH, UK.
⁸ Center for Biotechnology and Genomics, Texas Tech University, Lubbock, TX, USA.
⁹ Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, 99199-91766, Iran.

PMID: 39506439
DOI: 10.2174/0118715257297949241023053739

Abstract

Background: Premature menopause (PM) is defined as the end of ovulation before the age of 40 years, a condition commonly referred to as primary ovarian insufficiency. It has been shown there is an association between early menopause and a high risk of cardiovascular disease.

Aim: This study aimed to evaluate the effect of genetic polymorphisms related to premature menopause on cardio-metabolic disorders Objective: We aimed to investigate the single nucleotide polymorphisms associated with PM and the risk of cardio-metabolic disorders in the MASHAD cohort study.

Methods: In this cross-sectional study, a total of 117 women with PM were recruited and compared with 183 healthy women. All participants were assessed for anthropometric indices and genotyped for eight selected polymorphisms within seven different genes.

Results: A significant difference was observed in physical activity level (PAL) between the groups. Individuals with rs4806660 CC genotype had a 3.63-fold increased risk of metabolic syndrome. Moreover, individuals with a TT genotype of the rs2303369 polymorphism had a 3.11-- fold increased risk of obesity.

Conclusion: Our findings showed that genetic variations are risk factors related to cardio- metabolic disorders in women with premature menopause.

Keywords: Polymorphism; cardiovascular; cohort; genetic; premature menopause; variant..