Bioinspired injectable hydrogels for bone regeneration

Xuan Tang; Fengjin Zhou; Sicheng Wang; Guangchao Wang; Long Bai; Jiacan Su

doi:10.1016/j.jare.2024.10.032

Bioinspired injectable hydrogels for bone regeneration

J Adv Res. 2024 Nov 5:S2090-1232(24)00486-7. doi: 10.1016/j.jare.2024.10.032. Online ahead of print.

Authors

Xuan Tang¹, Fengjin Zhou², Sicheng Wang³, Guangchao Wang⁴, Long Bai⁵, Jiacan Su⁶

Affiliations

¹ Organoid Research Center, Institute of Translational Medicine, Shanghai University, Shanghai 200444, China; National Center for Translational Medicine (Shanghai) SHU Branch, Shanghai University, Shanghai 200444, China.
² Department of Orthopaedics, Honghui Hospital, Xi'an Jiao Tong University, Xi'an 710000, China.
³ National Center for Translational Medicine (Shanghai) SHU Branch, Shanghai University, Shanghai 200444, China; Department of Orthopedics Trauma, Shanghai Zhongye Hospital, Shanghai 201900, China.
⁴ Department of Orthopedics, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China. Electronic address: wgc@shsmu.edu.cn.
⁵ Organoid Research Center, Institute of Translational Medicine, Shanghai University, Shanghai 200444, China; National Center for Translational Medicine (Shanghai) SHU Branch, Shanghai University, Shanghai 200444, China; Wenzhou Institute of Shanghai University, Wenzhou 325000, China. Electronic address: bailong@shu.edu.cn.
⁶ Organoid Research Center, Institute of Translational Medicine, Shanghai University, Shanghai 200444, China; Department of Orthopedics, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China; National Center for Translational Medicine (Shanghai) SHU Branch, Shanghai University, Shanghai 200444, China. Electronic address: drsujiacan@163.com.

PMID: 39505143
DOI: 10.1016/j.jare.2024.10.032

Abstract

The effective regeneration of bone/cartilage defects remains a significant clinical challenge, causing irreversible damage to millions annually.Conventional therapies such as autologous or artificial bone grafting often yield unsatisfactory outcomes, emphasizing the urgent need for innovative treatment methods. Biomaterial-based strategies, including hydrogels and active scaffolds, have shown potential in promoting bone/cartilage regeneration. Among them, injectable hydrogels have garnered substantial attention in recent years on account of their minimal invasiveness, shape adaptation, and controlled spatiotemporal release. This review systematically discusses the synthesis of injectable hydrogels, bioinspired approaches-covering microenvironment, structural, compositional, and bioactive component-inspired strategies-and their applications in various bone/cartilage disease models, highlighting bone/cartilage regeneration from an innovative perspective of bioinspired design. Taken together, bioinspired injectable hydrogels offer promising and feasible solutions for promoting bone/cartilage regeneration, ultimately laying the foundations for clinical applications. Furthermore, insights into further prospective directions for AI in injectable hydrogels screening and organoid construction are provided.

Keywords: Advanced biotechnology; Bioinspired; Bone regeneration; Cartilage regeneration; Injectable hydrogels.

Publication types

Review