Nanomaterials for stroke diagnosis and treatment

Yang Liu; Junying Li; Huaijuan Guo; Chao Fang; Qiaoling Yang; Wen Qin; Hai Wang; Yong Xian; Xuebing Yan; Binxu Yin; Kun Zhang

doi:10.1016/j.isci.2024.111112

Nanomaterials for stroke diagnosis and treatment

iScience. 2024 Oct 9;27(11):111112. doi: 10.1016/j.isci.2024.111112. eCollection 2024 Nov 15.

Authors

Yang Liu^{1

2}, Junying Li³, Huaijuan Guo², Chao Fang², Qiaoling Yang², Wen Qin², Hai Wang², Yong Xian², Xuebing Yan^{1

4}, Binxu Yin², Kun Zhang²

Affiliations

¹ Department of Oncology, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, Jiangsu, China.
² Department of Pharmacy and Central Laboratory, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, No. 32, West Second Section, First Ring Road, Chengdu 610072, China.
³ Instrumentation and Service Center for Science and Technology, Beijing Normal University, No. 18 Jinfeng Road, Zhuhai 519087, Guangdong Province, China.
⁴ Jiangsu Provincial Innovation and Practice Base for Postdoctors, Suining People's Hospital, Affiliated Hospital of Xuzhou Medical University, Suining 221200, China.

Abstract

Nanomaterials and nanotechnology innovations possess unique physicochemical properties that present new opportunities in the realm of stroke detection, diagnosis, and treatment. This comprehensive review explores the utilization of nanomaterials in the diagnosis and treatment of strokes, encompassing recent advancements in computed tomography (CT), magnetic resonance imaging (MRI) and magnetic particle imaging (MPI), as well as groundbreaking applications of nanomaterials and bionanomaterials in drug delivery systems and brain tissue repair. Additionally, this review meticulously examines significant challenges such as biocompatibility toxicity and long-term safety, proposing potential strategies to surmount these obstacles. Moreover, this review delves into the application of nanomaterials to improve the clinical diagnosis of stroke patients, elucidates the potential of nanotechnology in post-stroke therapy, and identifies future research directions and potential clinical applications.

Keywords: Biomedical materials; Diagnostics; Nanomaterials; Therapeutics.

Publication types

Review