An evolutionary perspective on Arf family GTPases

Catherine L Jackson; Julie Ménétrey; Mandeep Sivia; Joel B Dacks; Marek Eliáš

doi:10.1016/j.ceb.2023.102268

An evolutionary perspective on Arf family GTPases

Curr Opin Cell Biol. 2023 Oct 27:85:102268. doi: 10.1016/j.ceb.2023.102268. Online ahead of print.

Authors

Catherine L Jackson¹, Julie Ménétrey², Mandeep Sivia³, Joel B Dacks³, Marek Eliáš⁴

Affiliations

¹ Université Paris Cité, CNRS, Institut Jacques Monod, F-75013 Paris, France. Electronic address: cathy.jackson@ijm.fr.
² Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198, Gif-sur-Yvette, France.
³ Division of Infectious Disease, Department of Medicine, University of Alberta, Edmonton, AB T6G 2H7, Canada.
⁴ Department of Biology and Ecology, Faculty of Science, University of Ostrava, Ostrava, Czech Republic.

PMID: 39491309
DOI: 10.1016/j.ceb.2023.102268

Abstract

The Arf family GTPases are regulators of eukaryotic cellular organization, functioning in the secretory and endocytic pathways, in cilia and flagella, in cytoskeleton dynamics, and in lipid metabolism. We describe the evolution of this protein family and its well-studied regulators. The last eukaryotic common ancestor had fifteen members, and the current complement of Arf GTPases has been sculpted by gene loss and gene duplications since that point. Some Arf family GTPases (such as those that recruit vesicle coats in the secretory pathway) are present in virtually all eukaryotes, whereas others (such as those functioning in cilia/flagella) have a more limited distribution. A challenge for the future is understanding the full spectrum of Arf family functions throughout eukaryotes.

Publication types

Review