Research progress of ischemia-free liver transplantation

Ming-Xi Zhang; Qiang Zhao; Xiao-Shun He

doi:10.1016/j.hbpd.2024.10.002

Research progress of ischemia-free liver transplantation

Hepatobiliary Pancreat Dis Int. 2024 Oct 22:S1499-3872(24)00126-7. doi: 10.1016/j.hbpd.2024.10.002. Online ahead of print.

Authors

Ming-Xi Zhang¹, Qiang Zhao¹, Xiao-Shun He²

Affiliations

¹ Organ Transplant Center, First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510000, China; Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou 510000, China.
² Organ Transplant Center, First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510000, China; Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou 510000, China. Electronic address: gdtrc@163.com.

PMID: 39489635
DOI: 10.1016/j.hbpd.2024.10.002

Abstract

Ischemia-reperfusion injury (IRI) is an inherent issue in organ transplantation. Because of the allograft shortage, more and more extended criteria donor (ECD) organs are used, unfortunately these grafts are more susceptible to IRI. Although machine perfusion technology has brought hope to alleviate IRI, this technology is still unable to eradicate IRI-related organ damage. Ischemia-free liver transplantation (IFLT) can completely avoid IRI, thereby improve graft function and recipient outcome, and allow to expand organ pool. This review summarized the latest progresses in IFLT, and speculated the future development of this concept.

Keywords: Ischemia-free liver transplantation; Ischemia-reperfusion injury; Normothermic machine perfusion.

Publication types

Review