Pleural mesothelioma (PMe) was associated with asbestos exposure.The Diagnosis of PMe is difficult due to the lack of specificity of clinical signs and symptoms, although there are many tools available for early diagnosis of mesothelioma. Most PMe patients are diagnosed at an advanced stage. This article reviews advances in strategies for early diagnosis of mesothelioma, focusing on breath analysis, early diagnosis of pleural effusion cytology in patients with mesothelioma, serum biomarkers and miRNA.
胸膜间皮瘤（PMe）与接触石棉有关，尽管目前有许多间皮瘤的早期诊断工具，但由于临床症状和体征缺乏特异性，诊断仍较为困难，多数PMe患者被确诊时已为晚期。本文就PMe早期诊断策略方面的进展进行综述，这些策略有助于间皮瘤的早期诊断，研究重点集中在呼气分析、间皮瘤患者胸腔积液细胞学早期诊断、血清生物标志物及miRNA等。.
Keywords: Diagnosis; Early diagnosis; Malignant pleural mesothelioma; Mesothelioma; Micro RNA.