Effect of combination of uterine artery doppler and vitamin D level on perinatal outcomes in second trimester pregnant women

Gokhan Tosun; Ayca Nazli Akar; Derya Burkankulu; Venhar Ceyhan; Emine Aydin

doi:10.1515/jpm-2024-0274

Effect of combination of uterine artery doppler and vitamin D level on perinatal outcomes in second trimester pregnant women

J Perinat Med. 2024 Oct 28. doi: 10.1515/jpm-2024-0274. Online ahead of print.

Authors

Gokhan Tosun¹, Ayca Nazli Akar¹, Derya Burkankulu², Venhar Ceyhan³, Emine Aydin⁴

Affiliations

¹ Izmir Faculty of Medicine, Department of Obstetrics and Gynecology, 448249 University of Health Sciences, Turkey , Izmir, Türkiye.
² Department of Obstetrics and Gynecology, Izmir Democracy University, Buca Seyfi Demirsoy Education and Research Hospital, Izmir, Türkiye.
³ Department of Obstetrics and Gynecology, Kayseri City Education and Research Hospital, Kayseri, Türkiye.
⁴ Department of Obstetrics and Gynecology, Division of Perinatology, Istanbul Medipol University, Istanbul, Türkiye.

PMID: 39460638
DOI: 10.1515/jpm-2024-0274

Abstract

Objectives: To investigate the effect of the combination of uterine artery (UtA) Doppler and vitamin D levels on perinatal outcomes in second trimester pregnants was aimed.

Methods: UtA Dopplers and vitamin D levels of 226 pregnant women in the second trimester were measured. Patients were followed for adverse pregnancy outcomes. The relationship of this combination with these pregnancy outcomes was evaluated.

Results: Sensitivity and specificity values are respectively; Left UtA-S/D ratio for preeclampsia was 85.29 and 81.77 %, left UtA-RI was 90.62 and 43.30 % for preterm birth, and 76.19 and 66.34 % for the development of fetal distress had the best predictive effect. Vitamin D values had no predictive value for any parameter (p>0.005).

Conclusions: UtA Doppler has a good predictive value for many adverse pregnancy outcomes. However, in order to correlate these results with second trimester vitamin D levels, more homogeneous and specific groups are needed.

Keywords: fetal growth restriction; preeclampsia; premature birth; uterine artery Doppler; vitamin D.