Physivitrins I-R, lanostane triterpenoids with anti-inflammatory activities from the fungus Physisporinus vitreus

Phytochemistry. 2025 Jan:229:114314. doi: 10.1016/j.phytochem.2024.114314. Epub 2024 Oct 22.

Abstract

Chemical investigation on the rice fermentation of the fungus Physisporinus vitreus led to the isolation of ten previously undescribed lanostane triterpenoids, physivitrins I-R, and three known analogues. The new structures were elucidated on the basis of extensive spectroscopic methods, including 1D & 2D NMR, HRESIMS, UV and ECD. Physivitrins I and P exhibited significant inhibitory activities against NO production in LPS-activated RAW267.4 macrophages with IC50 values of 8.2 and 11.5 μM, respectively. The comprehensive data indicated that P. vitreus is rich in lanostane triterpenes and has potential anti-inflammatory application prospects.

Keywords: Lanostane triterpenoids; NO production inhibition; Physisporinus vitreus; Polyporaceae.

MeSH terms

  • Animals
  • Anti-Inflammatory Agents* / chemistry
  • Anti-Inflammatory Agents* / isolation & purification
  • Anti-Inflammatory Agents* / pharmacology
  • Ascomycota / chemistry
  • Dose-Response Relationship, Drug
  • Lipopolysaccharides* / antagonists & inhibitors
  • Lipopolysaccharides* / pharmacology
  • Macrophages* / drug effects
  • Mice
  • Molecular Conformation
  • Molecular Structure
  • Nitric Oxide* / antagonists & inhibitors
  • Nitric Oxide* / biosynthesis
  • RAW 264.7 Cells
  • Structure-Activity Relationship
  • Triterpenes* / chemistry
  • Triterpenes* / isolation & purification
  • Triterpenes* / pharmacology

Substances

  • Triterpenes
  • Nitric Oxide
  • Lipopolysaccharides
  • Anti-Inflammatory Agents