Generation of patient-derived induced pluripotent stem cell line UJSi004-A from ultra-treatment-resistant schizophrenia

Siyu Xi; Bing Xue; Yupeng Wang; Zhenghua Shan; Tianchi Song; Jing Sun; Shengying Qin

doi:10.1016/j.scr.2024.103575

Generation of patient-derived induced pluripotent stem cell line UJSi004-A from ultra-treatment-resistant schizophrenia

Stem Cell Res. 2024 Oct 9:81:103575. doi: 10.1016/j.scr.2024.103575. Online ahead of print.

Authors

Siyu Xi¹, Bing Xue¹, Yupeng Wang¹, Zhenghua Shan¹, Tianchi Song², Jing Sun³, Shengying Qin⁴

Affiliations

¹ Neurobiology & Mitochondrial Key Laboratory, Effective & Toxicity Monitoring Innovative Practice Center for Food Pharmaceutical Specialty, School of Pharmacy, Jiangsu University, Zhenjiang 212013, PR China.
² Medical School, Nantong University, Nantong 226001, PR China.
³ Neurobiology & Mitochondrial Key Laboratory, Effective & Toxicity Monitoring Innovative Practice Center for Food Pharmaceutical Specialty, School of Pharmacy, Jiangsu University, Zhenjiang 212013, PR China. Electronic address: sjyancheng@ujs.edu.cn.
⁴ Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Bio-X Institutes, Shanghai Jiao Tong University, Shanghai 200030, PR China. Electronic address: chinsir@sjtu.edu.cn.

PMID: 39423675
DOI: 10.1016/j.scr.2024.103575

Abstract

Schizophrenia is a severe mental illness with disabling effects. Induced pluripotent stem cells (iPSCs) are generated by reprogramming peripheral blood mononuclear cells (PBMCs) from patients with ultra-treatment-resistant schizophrenia (UTRS). iPSCs have normal karyotype, express pluripotency markers and differentiate into three germ layers in vivo. This iPSC cell line carries the genetic information of the patient and is a good model for studying disease mechanisms and developing new therapies.