The genetic landscape underlying the transformation of splenic diffuse red pulp small B-cell lymphoma (SDRPL) is not well understood. The present study aimed to unravel the genomic alterations involved in the progression and transformation of SDRPL. We performed genetic studies on both SDRPL and subsequent or synchronous diffuse large B cell lymphoma (DLBCL) samples in three SDRPL patients who eventually developed DLBCL. Our findings revealed that SDRPL cases progressing to DLBCL acquired genomic alterations in genes related to the cell cycle (CDKN2A/B, TP53, MYC and CCND3) and B cell development (BCL6).
Keywords: B‐cell developement; cell cycle; clonal relationship; genetic alterations; histologic transformation; splenic diffuse red pulp small B‐cell lymphoma.
© 2024 The Author(s). eJHaem published by British Society for Haematology and John Wiley & Sons Ltd.