In a secondary analysis, we examine how trust in pro-recommendation versus alternative communication channels mediated effects of demographic, personality, lifestyle, and political variables on COVID-19 protective behavior in England. In so doing, we adapt the media-as-mediator approach to the pandemic context. Respondents reported that family, close friends, primary care medical providers, and mainstream news media were relatively supportive of public health recommendations, and social media friend networks, faith/community groups, alternative news sites, and alternative health practitioners were relatively unsupportive. Parallel mediation analyses showed that effects of age, dutiful civic-mindedness, sensation-seeking, healthy lifestyle orientation, and more marginally, race on COVID-19 protective behavior were mediated by trust in these pro-recommendation and/or alternative communication channels. In some cases, trust in exemplars of both types of channels resulted in these channels influences largely canceling one another out.