Establishment of an induced pluripotent stem cell (iPSC) line (JNMUi002-A) from a male patient with schizophrenia

Meixiang Jiang; Yuxing Long; Yiliang Liu; Ran Li; Jingyi Xu; Tongyue Chi; Menglu Sun; Miao Li; Hao Yu; Lu Yu; Xiaobo Han

doi:10.1016/j.scr.2024.103570

Establishment of an induced pluripotent stem cell (iPSC) line (JNMUi002-A) from a male patient with schizophrenia

Stem Cell Res. 2024 Sep 30:81:103570. doi: 10.1016/j.scr.2024.103570. Online ahead of print.

Authors

Meixiang Jiang¹, Yuxing Long¹, Yiliang Liu¹, Ran Li¹, Jingyi Xu¹, Tongyue Chi¹, Menglu Sun¹, Miao Li¹, Hao Yu¹, Lu Yu², Xiaobo Han³

Affiliations

¹ Shandong Key Laboratory of Psychiatric and Behavioral Medicine, School of Mental Health, Jining Medical University, Jining 272013, Shandong, China; Shandong Collaborative Innovation Center for Diagnosis, Treatment and Behavioral Interventions of Mental Disorders, Jining Medical University, Jining 272013, Shandong, China.
² Institute of Immunology and Molecular Medicine, Jining Medical University, Jining, China.
³ Shandong Key Laboratory of Psychiatric and Behavioral Medicine, School of Mental Health, Jining Medical University, Jining 272013, Shandong, China; Shandong Collaborative Innovation Center for Diagnosis, Treatment and Behavioral Interventions of Mental Disorders, Jining Medical University, Jining 272013, Shandong, China. Electronic address: han_xiaobo@mail.jnmc.edu.cn.

PMID: 39368271
DOI: 10.1016/j.scr.2024.103570

Abstract

We obtained Peripheral blood mononuclear cells (PBMCs) from a peripheral blood sample of a 19-year-old male schizophrenia patient and successfully established induced pluripotent stem cell (iPSC) line using non-integrated reprogramming technology. This cell line possesses the correct karyotype, shape of an embryonic stem cell, the ability to express particular pluripotency markers, and the capacity to differentiate into three germ layers in vitro. This cell line will serve as an in vitro model for upcoming studies on the etiology of schizophrenia and the creation of novel treatment.