In the history of medical science and public health in India, the groundbreaking research on cholera toxin by Dr. Sambhu Nath De presents a pivotal moment. This review article dives into Dr. De's influential contributions to the understanding of cholera pathogenesis, his discovery of the cholera toxin, and its implications for the treatment and prevention of diseases. By defining the process via which vibrio cholera causes severe diarrhea and dehydration, Dr. De worked toward paving the way for the development of effective rehydration therapies and preventive strategies that have helped save innumerable lives all over the world. This article also reviews the more significant impact of Dr. De's findings in the field of public health and its shaping and use of modern approaches to infectious control. This article aims to honor the enduring legacy and contributions to public health reform by Dr. De.
Keywords: cholera toxin; historical vignettes; intestinal loop model; oral rehydration therapy; public health.
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