Lipid-based nanoparticles: innovations in ocular drug delivery

Mirza Salman Baig; Shweta Kulkarni Karade; Anas Ahmad; Mohd Ashif Khan; Anzarul Haque; Thomas J Webster; Md Faiyazuddin; Noora H Al-Qahtani

doi:10.3389/fmolb.2024.1421959

Lipid-based nanoparticles: innovations in ocular drug delivery

Front Mol Biosci. 2024 Sep 17:11:1421959. doi: 10.3389/fmolb.2024.1421959. eCollection 2024.

Authors

Mirza Salman Baig¹, Shweta Kulkarni Karade², Anas Ahmad³, Mohd Ashif Khan⁴, Anzarul Haque⁵, Thomas J Webster^{6

7

8

9}, Md Faiyazuddin^{10

11}, Noora H Al-Qahtani^{5

12}

Affiliations

¹ Anjuman-I-Islam's Kalsekar Technical Campus School of Pharmacy, Affiliated to the University of Mumbai, New Panvel, Maharashtra, India.
² DY Patil Deemed to be University- School of Pharmacy, Navi Mumbai, India.
³ Department of Microbiology, Immunology and Infectious Diseases, Cumming School of Medicine, University of Calgary, Alberta, Canada.
⁴ Centre for Translational and Clinical Research, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi, India.
⁵ Central Laboratories Unit (CLU), Qatar University, Doha, Qatar.
⁶ School of Health Science and Biomedical Engineering, Hebei University of Technology, Tianjin, China.
⁷ School of Engineering, Saveetha University, Chennai, India.
⁸ Program in Materials, UFPI, Teresina, Brazil.
⁹ Division of Pre-College and Undergraduate Studies, Brown University, Providence, RI, United States.
¹⁰ School of Pharmacy, Al - Karim University, Katihar, Bihar, India.
¹¹ Centre for Global Health Research, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India.
¹² Center for Advanced Materials, Qatar University, Doha, Qatar.

Abstract

Ocular drug delivery presents significant challenges due to intricate anatomy and the various barriers (corneal, tear, conjunctival, blood-aqueous, blood-retinal, and degradative enzymes) within the eye. Lipid-based nanoparticles (LNPs) have emerged as promising carriers for ocular drug delivery due to their ability to enhance drug solubility, improve bioavailability, and provide sustained release. LNPs, particularly solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), and cationic nanostructured lipid carriers (CNLCs), have emerged as promising solutions for enhancing ocular drug delivery. This review provides a comprehensive summary of lipid nanoparticle-based drug delivery systems, emphasizing their biocompatibility and efficiency in ocular applications. We evaluated research and review articles sourced from databases such as Google Scholar, TandFonline, SpringerLink, and ScienceDirect, focusing on studies published between 2013 and 2023. The review discusses the materials and methodologies employed in the preparation of SLNs, NLCs, and CNLCs, focusing on their application as proficient carriers for ocular drug delivery. CNLCs, in particular, demonstrate superior effectiveness attributed due to their electrostatic bioadhesion to ocular tissues, enhancing drug delivery. However, continued research efforts are essential to further optimize CNLC formulations and validate their clinical utility, ensuring advancements in ocular drug delivery technology for improved patient outcomes.

Keywords: cationic nanostructured lipid carriers; lipid nanoparticles; nanomedicine; nanostructured lipid carriers; ocular drug delivery; ophthalmic drug delivery; solid lipid nanoparticles.

Publication types

Review

Grants and funding

The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. The publication of the article was financially supported by the Qatar National Library. The statements made herein are solely the responsibility of the authors.