DNA Methylation-Derived Immune Cell Proportions and Cancer Risk in Black Participants

Cancer Res Commun. 2024 Oct 1;4(10):2714-2723. doi: 10.1158/2767-9764.CRC-24-0257.

Abstract

This study describes associations between immune cell types and cancer risk in a Black population; elevated regulatory T-cell proportions that were associated with increased overall cancer and lung cancer risk, and elevated memory B-cell proportions that were associated with increased prostate and all cancer risk.

MeSH terms

  • Adult
  • Aged
  • B-Lymphocytes / immunology
  • Black or African American* / genetics
  • DNA Methylation*
  • Female
  • Humans
  • Lung Neoplasms / epidemiology
  • Lung Neoplasms / genetics
  • Lung Neoplasms / immunology
  • Male
  • Middle Aged
  • Neoplasms* / epidemiology
  • Neoplasms* / genetics
  • Neoplasms* / immunology
  • Risk Factors
  • T-Lymphocytes, Regulatory / immunology