Validation of the Generic Version of China Health Related Outcomes Measures (CHROME-G) among individuals with type 2 diabetes in China

Meixuan Li; Shitong Xie; Minyan Yang; Yanan Wu; Zijun Li; Rui Li; Xiuxia Li; Xue Li; Yijun Liu; Jing Wu; Kun Zhao; Feng Xie; Kehu Yang

doi:10.1111/jebm.12642

Validation of the Generic Version of China Health Related Outcomes Measures (CHROME-G) among individuals with type 2 diabetes in China

J Evid Based Med. 2024 Sep 24. doi: 10.1111/jebm.12642. Online ahead of print.

Authors

Meixuan Li^{1

2

3}, Shitong Xie^{4

5}, Minyan Yang^{1

2

3}, Yanan Wu^{2

3}, Zijun Li^{2

3}, Rui Li⁶, Xiuxia Li^{1

2

3}, Xue Li⁶, Yijun Liu⁷, Jing Wu^{4

5}, Kun Zhao^{6

8}, Feng Xie⁹, Kehu Yang^{1

2

3}

Affiliations

¹ Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, Gansu, China.
² Evidence-Based Social Science Research Center, Health Technology Assessment Center, School of Public Health, Lanzhou University, Lanzhou, Gansu, China.
³ Gansu Key Laboratory of Evidence-Based Medicine, Lanzhou University, Lanzhou, Gansu, China.
⁴ School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, China.
⁵ Center for Social Science Survey and Data, Tianjin University, Tianjin, China.
⁶ Department of Health Technology Assessment, China National Health Development Research Center, Beijing, China.
⁷ Department of Integrated Traditional Chinese and Western Medicine, Wuwei People's Hospital, Wuwei, Gansu, China.
⁸ Vanke School of Public Health, Tsinghua University, Beijing, China.
⁹ Faculty of Health Sciences, Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.

PMID: 39314139
DOI: 10.1111/jebm.12642

Abstract

Objective: The Generic Version of China Health Related Outcomes Measures (CHROME-G) was a new preference-based health-related quality of life (HRQoL) instrument designed specifically for the Chinese population. This study aimed to validate and compare measurement properties of CHROME-G with EuroQol-5 Dimensions-5 Levels (EQ-5D-5L), Short Form-6 Dimensions version 2 (SF-6Dv2), and Diabetes-Specific Quality of Life (DSQL) scales among the elderly Chinese population with type 2 diabetes.

Methods: A representative sample population was recruited across the country. Internal consistency was assessed using Cronbach's alpha. Hypotheses testing including convergent validity and known-groups validity were evaluated using Spearman's rank correlation and effect sizes, respectively. Sensitivity was examined using relative efficiency and receiver operating characteristic curve.

Results: A total of 131 individuals with type 2 diabetes (54.20% male; mean age 69.03 years) were enrolled. Cronbach's alpha was 0.94 for DSQL, 0.93 for CHROME-G, 0.87 for EQ-5D-5L, and 0.88 for SF-6Dv2. For the convergent validity of CHROME-G, 24/29 (82.76%) correlations met the predefined hypotheses, with Spearman's rank correlation coefficients ranging from 0.51 to 0.96. Among the different health subgroups, the effect sizes for CHROME-G, DSQL, EQ-5D-5L, and SF-6Dv2 were 0.19-1.26, 0.36-1.62, 0.22-1.06, and 0.49-0.87, respectively. CHROME-G, DSQL, and SF-6Dv2 had higher efficiency compared with EQ-5D-5L in detecting differences in self-reported health status, with relative efficiency of 3.18 and 1.76, 4.38 and 6.52, and 1.56 and 2.09, respectively.

Conclusions: CHROME-G demonstrates relatively good measurement properties compared with EQ-5D-5L and SF-6Dv2 for measuring the HRQoL among the elderly Chinese population with type 2 diabetes. The sensitivity of DSQL appears to be better than that of the three generic instruments.

Keywords: CHROME‐G; China; health‐related quality of life; measurement properties; older adults; type 2 diabetes.

Abstract

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