Aging and age-related ailments have emerged as critical challenges and great burdens within the global contemporary society. Addressing these concerns is an imperative task, with the aims of postponing the aging process and finding effective treatments for age-related degenerative diseases. Recent investigations have highlighted the significant roles of nicotinamide adenine dinucleotide (NAD+) in the realm of anti-aging. It has been empirically evidenced that supplementation with nicotinamide mononucleotide (NMN) can elevate NAD+ levels in the body, thereby ameliorating certain age-related degenerative diseases. The principal anti-aging mechanisms of NMN essentially lie in its impact on cellular energy metabolism, inhibition of cell apoptosis, modulation of immune function, and preservation of genomic stability, which collectively contribute to the deferral of the aging process. This paper critically reviews and evaluates existing research on the anti-aging mechanisms of NMN, elucidates the inherent limitations of current research, and proposes novel avenues for anti-aging investigations.
老龄化和年龄相关疾病已成为全球当代社会面临的重大挑战和沉重负担。解决这些问题是一项势在必行的任务，其目的是延缓衰老过程，并找到与年龄有关的退行性疾病的有效治疗方法。最近的研究强调了烟酰胺腺嘌呤二核苷酸（NAD+）在抗衰老领域的重要作用。经验证明，补充烟酰胺单核苷酸（NMN）可以提高体内NAD+水平，从而改善某些与年龄相关的退行性疾病。NMN的抗衰老机制主要在于其对细胞能量代谢的影响、对细胞凋亡的抑制、对免疫功能的调节和对基因组稳定性的保持，这些共同延缓了衰老进程。本文对NMN抗衰老机制的现有研究进行了批判性的回顾和评价，阐明了当前研究的内在局限性，并提出了抗衰老研究的新途径。.
老龄化和年龄相关疾病已成为全球当代社会面临的重大挑战和沉重负担。解决这些问题是一项势在必行的任务，其目的是延缓衰老过程，并找到与年龄有关的退行性疾病的有效治疗方法。最近的研究强调了烟酰胺腺嘌呤二核苷酸（NAD+）在抗衰老领域的重要作用。经验证明，补充烟酰胺单核苷酸（NMN）可以提高体内NAD+水平，从而改善某些与年龄相关的退行性疾病。NMN的抗衰老机制主要在于其对细胞能量代谢的影响、对细胞凋亡的抑制、对免疫功能的调节和对基因组稳定性的保持，这些共同延缓了衰老进程。本文对NMN抗衰老机制的现有研究进行了批判性的回顾和评价，阐明了当前研究的内在局限性，并提出了抗衰老研究的新途径。
Keywords: Anti-aging; Apoptosis; DNA repair; Energy metabolism; Nicotinamide mononucleotide (NMN).