Association between the platelet/high-density lipoprotein cholesterol ratio and depression: A cross-sectional analysis in United States adults

Chenle Ye; Guangzhan Chen; Weikai Huang; Yuanrun Liu; Zhuoqi He; Mingjie Hu; Guangce Deng; Ling Qi; Kaishu Li

doi:10.1016/j.jad.2024.09.123

Association between the platelet/high-density lipoprotein cholesterol ratio and depression: A cross-sectional analysis in United States adults

J Affect Disord. 2024 Sep 19:S0165-0327(24)01612-4. doi: 10.1016/j.jad.2024.09.123. Online ahead of print.

Authors

Chenle Ye¹, Guangzhan Chen¹, Weikai Huang¹, Yuanrun Liu¹, Zhuoqi He¹, Mingjie Hu², Guangce Deng³, Ling Qi¹, Kaishu Li⁴

Affiliations

¹ Institute of Digestive Disease of Guangzhou Medical University, Affiliated Qingyuan Hospital, Guangzhou Medical, Qingyuan People's Hospital, Qingyuan 511518, China.
² School of Economics and Management, Beihang University, Beijing 100191, China.
³ Department of Neurosurgery, Affiliated Qingyuan Hospital, Guangzhou Medical, Qingyuan People's Hospital, Qingyuan 511518, China.
⁴ Institute of Digestive Disease of Guangzhou Medical University, Affiliated Qingyuan Hospital, Guangzhou Medical, Qingyuan People's Hospital, Qingyuan 511518, China; Department of Neurosurgery, Affiliated Qingyuan Hospital, Guangzhou Medical, Qingyuan People's Hospital, Qingyuan 511518, China. Electronic address: kaishu_li@126.com.

PMID: 39306005
DOI: 10.1016/j.jad.2024.09.123

Abstract

Background: The primary objective of this study was to elucidate the relationship between the platelet/high-density lipoprotein cholesterol ratio (PHR) and the risk of depression in adults in the US.

Methods: We conducted a cross-sectional study using data from the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2016. Depression was assessed using the PHQ-9 questionnaire. Weighted multivariable logistic regression models and restricted cubic spline (RCS) models were used to study the relationship between PHR and the risk of depression. Subgroup and interaction analyses were performed to further understand these associations.

Results: A total of 21,454 participants were included in this study. After full adjustment, PHR was significantly positively correlated with depression (OR = 1.33, 95%CI: 1.03-1.73). When PHR was converted into a categorical variable based on quartiles (Q1-Q4), the highest quartile of PHR was associated with an increased risk of depression compared to the lowest reference group (OR = 1.22, 95%CI: 1.01-1.48). There was a linear dose-response relationship between PHR and the risk of depression (P-non-linear = 0.8038). The association remained significant in several subgroup analyses. However, the interaction test showed that none of the stratified variables were significant (all P for interaction >0.05).

Limitation: Using self-assessment scales and inability to assess causality.

Conclusion: This population-based cross-sectional study elucidated that PHR is significantly associated with an increased prevalence of depression in adults in the US.

Keywords: Cross-sectional study; Depression; NHANES; Platelet/high-density lipoprotein cholesterol ratio.