Newer mitochondrial dynamics and their role of calcium signalling in liver regeneration

Onkar Bedi; Vaibhav Sapra; Manish Kumar; Pawan Krishan

doi:10.1016/j.mito.2024.101969

Newer mitochondrial dynamics and their role of calcium signalling in liver regeneration

Mitochondrion. 2024 Sep 19:79:101969. doi: 10.1016/j.mito.2024.101969. Online ahead of print.

Authors

Onkar Bedi¹, Vaibhav Sapra², Manish Kumar², Pawan Krishan³

Affiliations

¹ Chitkara College of Pharmacy, Chitkara University, Punjab, India. Electronic address: onkar.bedi@chitkara.edu.in.
² Chitkara College of Pharmacy, Chitkara University, Punjab, India.
³ Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Punjab, India.

PMID: 39305943
DOI: 10.1016/j.mito.2024.101969

Abstract

Liver regeneration is a crucial process involved in cellular proliferation, differentiation, and tissue repair. Calcium signaling impact key pathways like hepatocyte growth factor-Met-tyrosine kinase (HGF-Met) transduction pathway, the epidermal growth factor receptor (EGFR) signaling and Ca-mediated nuclear SKHep1 cell proliferation pathway. Intracellular hepatocyte calcium stores are considered as base for the induction of ca-mediated regeneration process. Calcium signaling interplays with HGF, TGF-β, and NF-κB signaling, influence stem cell behavior and triggers MAPK cascade. The mitochondria calcium is impacting on liver rejuvenation by regulating apoptosis and cell division. In conclusion, it is stated that calcium-signaling holds promise for therapeutic liver interventions.

Keywords: Calcium; Health; Liver regeneration; Mitochondrial effects; Mortality; Pharmacy health.

Publication types

Review