Ultra-small platinum nano-enzymatic spray with ROS scavenging and anti-inflammatory properties for photoaging treatment

Chunying Li; Yilin Wan; Jin Yang; ChunMei Feng; Jia Liu; Zhi Cao; Chunxiao Li; Peiru Wang; Xiuli Wang; Qingyu Zeng

doi:10.1016/j.ijbiomac.2024.135743

Ultra-small platinum nano-enzymatic spray with ROS scavenging and anti-inflammatory properties for photoaging treatment

Int J Biol Macromol. 2024 Sep 18:135743. doi: 10.1016/j.ijbiomac.2024.135743. Online ahead of print.

Authors

Chunying Li¹, Yilin Wan², Jin Yang¹, ChunMei Feng¹, Jia Liu¹, Zhi Cao¹, Chunxiao Li¹, Peiru Wang³, Xiuli Wang⁴, Qingyu Zeng⁵

Affiliations

¹ Institute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai 200040, China.
² Institute of Nano Biomedicine and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.
³ Institute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai 200040, China. Electronic address: wpeiru@qq.com.
⁴ Institute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai 200040, China. Electronic address: wangxiuli_1400023@tongji.edu.cn.
⁵ Institute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai 200040, China. Electronic address: zengqingyu2011@tongji.edu.cn.

PMID: 39304038
DOI: 10.1016/j.ijbiomac.2024.135743

Abstract

Photoaging induced by ultraviolet (UV) results in oxidative stress and inflammation. Noble metal nanozymes have strong antioxidant and anti-inflammatory capacity, which are expected to eliminate the excessive reactive oxygen species (ROS) and inflammatory factors in the photoaged skin. Hence, we have synthesized ultrasmall platinum nanoparticles coated with polyvinylpyrrolidone (Pt NPs) with a diameter of nearly 5 nm for photoaging treatment. Thanks to multi-enzymatic capacities (catalase, peroxidase, and superoxide dismutase) of Pt NPs, they can effectively protect fibroblasts from UV-induced ROS attack, relieve fibroblasts from UV-induced cell cycle arrest, downregulate matrix metalloproteinases (MMPs) to regenerate type I collagen, and inhibit M1 macrophage polarization to decrease the expression of inflammatory factors. For photoaged mice treatment, we employ the concept of routine spray skincare and encapsulate Pt NPs solution in a spray bottle. In combination with roller needle, following Pt NPs nano-enzymatic spray given, UV-induced photoaged mice display reduced wrinkle formation in the collagen-depleted dermal tissue of mice and more youthful performance in both appearance and organizational structure. Consequently, multi-enzymatic functions of Pt NPs nano-spray offers a promising avenue for anti-photoaging therapy, providing potential benefits in both preventative and restorative skincare applications.

Keywords: Collagen regeneration; Inflammation; Photoaging treatment; Pt NPs nano-enzymatic spray; Reactive oxygen species.