Fe(III)-catalyzed p-selective C-H bond chalcogenation of phenols

Org Biomol Chem. 2024 Oct 15;22(40):8133-8137. doi: 10.1039/d4ob01382d.

Abstract

An efficient, eco-friendly, and scalable protocol has been introduced for the p-selective C-X (X = Se/S) bond formation of phenols employing earth-abundant, less-toxic Fe(III)-catalysts and the green solvent ethanol without using any directing template, stabilizing ligands, oxidants, or additives. The key attraction lies in the impressive p-selectivity with moderate to good yields, wide functional group compatibility under mild aerobic reaction conditions, and the synthetic modification of the products towards value-added molecules.