Characterizing a stable five-species microbial community for use in experimental evolution and ecology

Microbiology (Reading). 2024 Sep;170(9):001489. doi: 10.1099/mic.0.001489.

Abstract

Model microbial communities are regularly used to test ecological and evolutionary theory as they are easy to manipulate and have fast generation times, allowing for large-scale, high-throughput experiments. A key assumption for most model microbial communities is that they stably coexist, but this is rarely tested experimentally. Here we report the (dis)assembly of a five-species microbial community from a metacommunity of soil microbes that can be used for future experiments. Using reciprocal invasion-from-rare experiments we show that all species can coexist and we demonstrate that the community is stable for a long time (~600 generations). Crucially for future work, we show that each species can be identified by their plate morphologies, even after >1 year in co-culture. We characterise pairwise species interactions and produce high-quality reference genomes for each species. This stable five-species community can be used to test key questions in microbial ecology and evolution.

Keywords: stability; coexistence; microbial community; model community.

MeSH terms

  • Bacteria* / classification
  • Bacteria* / genetics
  • Bacteria* / isolation & purification
  • Biological Evolution
  • Ecology
  • Microbial Interactions
  • Microbiota*
  • Soil Microbiology*