Background: Obesity and metabolic dysregulation (MetD) have increasing prevalence and adversely impact asthma morbidity and therapeutic response.
Objective: To determine the role of weight and MetD on incident asthma in adulthood.
Methods: In a retrospective, longitudinal cohort of patients, we performed a time-to-asthma diagnosis analysis after a three-year landmark period (t0-t3) during which weight and MetD components were examined. We assessed incident asthma risk with MetD components and weight.
Results: 90,081 patients met inclusion criteria with 836 (0.93%) cases of incident asthma in our primary cohort. Diabetes present at t0, but no other MetD components, was associated with increased risk of asthma (HRadj = 1.85, 95% CI: 1.27 - 2.71, p=0.0002). The effect of weight on asthma risk, independent of other MetD components, identified individuals who are overweight or obese as having a 10-year attributable risk of 15.4%. Metformin was prescribed more frequently and hemoglobin A1c levels were lower in patients with diabetes who did not develop asthma (p<0.0001).
Conclusion: Weight and diabetes prevention and management represent modifiable risk factors for adult asthma development.
Copyright © 2024. Published by Elsevier Inc.