Implementation of collaborative care for depression in VA HIV clinics: Translating Initiatives for Depression into Effective Solutions (HITIDES): protocol for a cluster-randomized type 3 hybrid effectiveness-implementation trial

Jacob T Painter; Jeffrey Pyne; Geoffrey Curran; Rebecca A Raciborski; Shane Russell; John Fortney; Allen L Gifford; Michael Ohl; Eva N Woodward

doi:10.1186/s43058-024-00639-z

Implementation of collaborative care for depression in VA HIV clinics: Translating Initiatives for Depression into Effective Solutions (HITIDES): protocol for a cluster-randomized type 3 hybrid effectiveness-implementation trial

Implement Sci Commun. 2024 Sep 16;5(1):99. doi: 10.1186/s43058-024-00639-z.

Authors

Jacob T Painter^{1

2

3

4}, Jeffrey Pyne^{5

6}, Geoffrey Curran⁷, Rebecca A Raciborski^{5

8

9}, Shane Russell⁵, John Fortney^{10

11}, Allen L Gifford^{12

13

14}, Michael Ohl^{15

16

17}, Eva N Woodward^{5

6}

Affiliations

¹ HSR&D Center of Innovation Center for Mental Healthcare and Outcomes Research, HSR&D Center of Innovation Center for Mental Healthcare and Outcomes Research, 2200 Fort Roots Dr, North Little Rock, AR, 72114, USA. JTPainter@uams.edu.
² Evidence, Policy, and Implementation Center, Central Arkansas Veterans Healthcare System, 2200 Fort Roots Dr, North Little Rock, AR, 72114, USA. JTPainter@uams.edu.
³ Division of Pharmaceutical Evaluation and Policy, College of Pharmacy, University of Arkansas for Medical Sciences, 4301 West Markham St, Little Rock, AR, 72205, USA. JTPainter@uams.edu.
⁴ Central Arkansas Veterans Healthcare System, 900 S Shackleford Rd, Little Rock, AR, 72211, USA. JTPainter@uams.edu.
⁵ HSR&D Center of Innovation Center for Mental Healthcare and Outcomes Research, HSR&D Center of Innovation Center for Mental Healthcare and Outcomes Research, 2200 Fort Roots Dr, North Little Rock, AR, 72114, USA.
⁶ Department of Psychiatry, College of Medicine, University of Arkansas for Medical Sciences, 4301 West Markham St, Little Rock, AR, 72205, USA.
⁷ Center for Implementation Research, Department of Pharmacy Practice, College of Pharmacy University of Arkansas for Medical Sciences, 4301 West Markham St, Little Rock, AR, 72205, USA.
⁸ Evidence, Policy, and Implementation Center, Central Arkansas Veterans Healthcare System, 2200 Fort Roots Dr, North Little Rock, AR, 72114, USA.
⁹ Behavioral Health Quality Enhancement Research Initiative (QUERI), Central Arkansas Veterans Healthcare System, 2200 Fort Roots Dr, North Little Rock, AR, 72114, USA.
¹⁰ Department of Psychiatry and Behavioral Sciences, School of Medicine, University of Washington, 1959 NE Pacific Street, Seattle, WA, 98195, USA.
¹¹ VA Health Systems Research, Center of Innovation for Veteran-Centered and Value-Driven Care, VA Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA, 98108, USA.
¹² Center for Healthcare Organization and Implementation Research, VA Boston Healthcare System, 150 S Huntington Ave, Boston, MA, 02130, USA.
¹³ Department of Medicine, Section of General Internal Medicine, Boston University Chobanian & Adevisian School of Medicine and Boston Medical Center, 72 East Concord St, Boston, MA, 02118, USA.
¹⁴ School of Public Health, Boston University, 715 Albany St, Boston, MA, 02118, USA.
¹⁵ Veterans Rural Health Resource Center - Iowa City Veterans Health Care System, 601 US-6 W, Iowa City, IA, 52246, USA.
¹⁶ Center for Access & Delivery Research and Evaluation (CADRE), Iowa City Veterans Affairs Health Care System, 601 US-6 W, Iowa City, IA, 52246, USA.
¹⁷ Department of Internal Medicine, University of Iowa Carver College of Medicine, 375 Newton Rd, Iowa City, IA, 52242, USA.

Abstract

Background: Depression is the most diagnosed mental health condition among people living with HIV. Collaborative care is an effective intervention for depression, typically delivered in primary care settings. The HIV Translating Initiatives for Depression into Effective Solutions (HITIDES) clinical intervention involves a depression care team housed off-site that supports depression care delivery by HIV care providers. In a randomized controlled trial, HITIDES significantly improved depression symptoms for veterans living with HIV and delivered cost savings. However, no HIV clinics in the Veterans Health Administration (VHA) have implemented HITIDES; as such, it is unclear what implementation strategies are necessary to launch and sustain this intervention.

Methods: This hybrid type-3 effectiveness-implementation trial examines the implementation and effectiveness of HITIDES in 8 VHA HIV clinics randomly assigned to one of two implementation arms. Each arm uses a different implementation strategy package. Arm 1 includes an intervention operations guide; an on-site clinical champion who, with the help of a peer community of practice, will work with local clinicians and leadership to implement HITIDES at their site; and patient engagement in implementation tools. Arm 2 includes all strategies from Arm 1 with assistance from an external facilitator. The primary implementation outcomes is reach; secondary outcomes include adoption, implementation dose, depressive symptoms, and suicidal ideation. We will conduct a budget impact analysis of the implementation strategy packages. We hypothesize that Arm 2 will be associated with greater reach and adoption and that Arm 1 will be less costly.

Discussion: Preliminary work identified implementation strategies acceptable to veterans living with HIV and HIV care providers; however, the effectiveness and cost of these strategies are unknown. While the depression care team can deliver services consistently with high quality, the ability of the depression care team to engage with HIV care providers at sites is unknown. Findings from this study will be used to inform selection of implementation strategies for a broad rollout to enhance depression and suicide care for people living with HIV.

Trial registration: ClinicalTrials.gov ID: NCT05901272, Registered 10 May 2023, https://clinicaltrials.gov/study/NCT05901272.

Keywords: Champion; Collaborative care; Consumer engagement; Cost; Depression; Economic evaluation; Facilitation; HIV; Implementation; Patient engagement.

Associated data

ClinicalTrials.gov/NCT05901272