Prominent loss of striatal dopamine transporter binding in frontotemporal lobar degeneration with the MAPT N279K mutation present as early as at prodromal stage without parkinsonism

Toji Miyagawa; Cynthia Vernon; Scott A Przybelski; Paul H Min; Julie A Fields; Bradford C Dickerson; Dennis W Dickson; Kejal Kantarci; Val J Lowe; Zbigniew K Wszolek; Bradley F Boeve

doi:10.1016/j.parkreldis.2024.107144

Prominent loss of striatal dopamine transporter binding in frontotemporal lobar degeneration with the MAPT N279K mutation present as early as at prodromal stage without parkinsonism

Parkinsonism Relat Disord. 2024 Nov:128:107144. doi: 10.1016/j.parkreldis.2024.107144. Epub 2024 Sep 8.

Authors

Affiliations

¹ Department of Neurology, Mayo Clinic, Rochester, MN, USA. Electronic address: Miyagawa.Toji@mayo.edu.
² Department of Radiology, Mayo Clinic, Rochester, MN, USA.
³ Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
⁴ Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.
⁵ Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
⁶ Department of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, FL, USA.
⁷ Department of Neurology, Mayo Clinic, Jacksonville, FL, USA.
⁸ Department of Neurology, Mayo Clinic, Rochester, MN, USA.

PMID: 39276720
DOI: 10.1016/j.parkreldis.2024.107144

Abstract

Our research found out, from ¹²³I-FP-CIT SPECT scans of three familial frontotemporal dementia (fFTD) individuals with MAPT N279K mutation and similar autopsy findings of frontotemporal degeneration with severe neuronal loss in the substantia nigra, that prominent decrease of dopamine transporter binding (z-score < -5.0) was present at prodromal fFTD without parkinsonism.

Keywords: 123I-FP-CIT SPECT; DaTQUANT; Familial FTLD; MAPT N279K; Parkinsonism.

Publication types

Letter

MeSH terms

Aged
Corpus Striatum / diagnostic imaging
Corpus Striatum / metabolism
Corpus Striatum / pathology
Dopamine Plasma Membrane Transport Proteins* / genetics
Dopamine Plasma Membrane Transport Proteins* / metabolism
Female
Frontotemporal Lobar Degeneration* / diagnostic imaging
Frontotemporal Lobar Degeneration* / genetics
Frontotemporal Lobar Degeneration* / metabolism
Frontotemporal Lobar Degeneration* / pathology
Humans
Male
Middle Aged
Mutation*
Parkinsonian Disorders / diagnostic imaging
Parkinsonian Disorders / genetics
Parkinsonian Disorders / metabolism
Prodromal Symptoms*
Tomography, Emission-Computed, Single-Photon*
Tropanes
tau Proteins* / genetics
tau Proteins* / metabolism

Substances

tau Proteins
Dopamine Plasma Membrane Transport Proteins
MAPT protein, human
2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane
Tropanes