Flavonol-Ruthenium Complexes as Antioxidant and Anticancer Agents

Ting-Wei Wu; Yi-Cheng Chu; Chuan-Hsin Chang; Yu-Hui Hsieh; Mei-Hsin Tang; Pei-Hsuan Hsu; Hsin-Ying Wu; Jih-Jung Chen; Tzenge-Lien Shih

doi:10.1002/cmdc.202400313

Flavonol-Ruthenium Complexes as Antioxidant and Anticancer Agents

ChemMedChem. 2024 Sep 11:e202400313. doi: 10.1002/cmdc.202400313. Online ahead of print.

Authors

Ting-Wei Wu¹, Yi-Cheng Chu^{2

3}, Chuan-Hsin Chang⁴, Yu-Hui Hsieh⁵, Mei-Hsin Tang¹, Pei-Hsuan Hsu¹, Hsin-Ying Wu¹, Jih-Jung Chen^{2

6

7}, Tzenge-Lien Shih¹

Affiliations

¹ Tamkang University, 251301 Tamsui Dist., New Taipei City, Taiwan.
² Department of Pharmacy, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, 112304, Taipei, Taiwan.
³ Department of Biotechnology and Pharmaceutical Technology, Yuanpei University of Medical Technology, 300102, Hsinchu, Taiwan.
⁴ Research Center for Chinese Herbal Medicine, Graduate Institute of Healthy Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, 333324, Taoyuan, Taiwan.
⁵ Biomedical Industry Ph.D. Program School of Life Sciences, National Yang Ming Chiao Tung University, 112304, Taipei, Taiwan.
⁶ Department of Medical Research, China Medical University Hospital, China Medical University, 404333, Taichung, Taiwan.
⁷ Traditional Herbal Medicine Research Center, Taipei Medical University Hospital, 110301, Taipei, Taiwan.

PMID: 39261284
DOI: 10.1002/cmdc.202400313

Abstract

Flavonol-metal complexes can enhance the biological activity of flavonols. Inspired by the potential of ruthenium-based drugs in pharmaceutical applications, seven flavonol-Ru (II) complexes were synthesized to evaluate their biological activities. Among these compounds, compounds 8, 11, and 12 showed potent antioxidant activities. Compound 12 exhibited superior anti-inflammatory activity to natural quercetin, which served as a positive control. This study is the first to report the free radical scavenging abilities and antioxidant activity of flavonol-Ru (II) complexes. Furthermore, compound 12 demonstrated comparable efficacy to 5-FU against human non-small-cell lung cancer cells (A549). These results strongly support the potential of flavonol-Ru (II) agents.

Keywords: Anti-inflammatory; Anticancer; Antioxidant; Flavonol; Flavonol-ruthenium complexes.

Abstract

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