Enhanced skin benefits of EGCG loaded in nonapeptide-1-conjugated mesoporous silica nanoparticles to reverse skin photoaging

Zeng-Jin Huang; Xin-Hui Zhou; Wei-Qiu Wen; Ze-Ting Huang; Jie Xuan; Ping Gui; Weihua Peng; Guanhai Wang

doi:10.1016/j.ijpharm.2024.124690

Enhanced skin benefits of EGCG loaded in nonapeptide-1-conjugated mesoporous silica nanoparticles to reverse skin photoaging

Int J Pharm. 2024 Sep 12:665:124690. doi: 10.1016/j.ijpharm.2024.124690. Online ahead of print.

Authors

Zeng-Jin Huang¹, Xin-Hui Zhou², Wei-Qiu Wen², Ze-Ting Huang³, Jie Xuan³, Ping Gui¹, Weihua Peng³, Guanhai Wang⁴

Affiliations

¹ The First Dongguan Affiliated Hospital, Guangdong Medical University, 523710 Dongguan, China.
² Huangpu Institute of Materials, Guangzhou, China.
³ Guangzhou Zhongzhuang Meiye Cosmetics Co., Ltd. Guangzhou, China.
⁴ The First Dongguan Affiliated Hospital, Guangdong Medical University, 523710 Dongguan, China. Electronic address: wangguanhai@gdmu.edu.cn.

PMID: 39260749
DOI: 10.1016/j.ijpharm.2024.124690

Abstract

Epigallocatechin-3-gallate (EGCG), a catechin present in green tea, has been studied extensively for its potential as a cosmetic ingredient due to its various biological properties. However, the low stability and bioavailability of EGCG have hindered its effective utilization in cosmetic applications. This study, to improve the stability and bioavailability of EGCG for reversing skin photo-aging, nonapeptide-1-conjugated mesoporous silica nanoparticles (EGCG@NP-MSN) were fabricated to load EGCG. MSNs can regulate the EGCG release and provide ultraviolet light (UV) protection to possess excellent photostability. Nonapeptide-1 exhibits melanin transfer interference properties and reduces the melanin content in treated skin areas. In vitro and in vivo results confirmed that the EGCG-loaded MSNs retained antioxidant properties, effectively scavenged the melanin and significantly reduced the deoxyribonucleic acid (DNA) damage in skin cells exposed to UV irradiation. The melanin inhibition rate is 5.22 times and the tyrosinase inhibition rate is 1.57 times that of free EGCG. The utilization of this innovative platform offers the potential for enhanced stability, controlled release, and targeted action of EGCG, thereby providing significant advantages for skin application.This delivery system combines the advantages of antioxidant, anti-aging, and anti-UV radiation properties, paving the way for the cosmetics development with improved efficacy and better performance in promoting skin health and appearance.

Keywords: EGCG; Nonapeptide-1; Photostability; Skin benefits; UV protection.