Microglia bridge brain activity and blood pressure

Yanxia Rao; Bo Peng

doi:10.1016/j.immuni.2024.08.006

Microglia bridge brain activity and blood pressure

Immunity. 2024 Sep 10;57(9):2000-2002. doi: 10.1016/j.immuni.2024.08.006.

Authors

Yanxia Rao¹, Bo Peng²

Affiliations

¹ Department of Neurosurgery, Huashan Hospital, Institute for Translational Brain Research, Department of Laboratory Animal Science, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases, Fudan University, Shanghai 200040, China.
² Department of Neurosurgery, Huashan Hospital, Institute for Translational Brain Research, Department of Laboratory Animal Science, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases, Fudan University, Shanghai 200040, China; Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu 226001, China. Electronic address: peng@fudan.edu.cn.

PMID: 39260350
DOI: 10.1016/j.immuni.2024.08.006

Abstract

Our brain is not an immune-privileged island isolated from peripheries, but how non-neuronal brain cells interact with the peripheral system is not well understood. Wei et al. report that microglia in the hypothalamic paraventricular nucleus (PVN) with unique vasculature can detect ATP derived from hemodynamic disturbance. These microglia in the PVN regulate the response to hypertension via ATP-P2Y12-C/EBPβ signaling.

MeSH terms

Adenosine Triphosphate / metabolism
Animals
Blood Pressure* / physiology
Brain* / immunology
CCAAT-Enhancer-Binding Protein-beta / metabolism
Humans
Hypertension / immunology
Hypertension / physiopathology
Microglia* / immunology
Microglia* / metabolism
Microglia* / physiology
Paraventricular Hypothalamic Nucleus* / immunology
Paraventricular Hypothalamic Nucleus* / metabolism
Paraventricular Hypothalamic Nucleus* / physiology
Signal Transduction

Substances

Adenosine Triphosphate
CCAAT-Enhancer-Binding Protein-beta