Axial length reduction and choroidal thickening with short-term exposure to cyan light in human subjects

Ranjay Chakraborty; Konogan Baranton; Eleonore Pic; Julia Didone; Wanki Kim; Kevin Lam; Alessandro Papandrea; Jad Kousa; Tiana Bhasme; Chloe Edmonds; Cindy Trieu; Eunjong Chang; Alexander Coleman; Azfira Hussain; Pascale Lacan; Daniel Spiegel; Coralie Barrau

doi:10.1111/opo.13390

Axial length reduction and choroidal thickening with short-term exposure to cyan light in human subjects

Ophthalmic Physiol Opt. 2024 Sep 8. doi: 10.1111/opo.13390. Online ahead of print.

Authors

Ranjay Chakraborty¹, Konogan Baranton², Eleonore Pic², Julia Didone¹, Wanki Kim¹, Kevin Lam¹, Alessandro Papandrea¹, Jad Kousa¹, Tiana Bhasme¹, Chloe Edmonds¹, Cindy Trieu¹, Eunjong Chang¹, Alexander Coleman¹, Azfira Hussain¹, Pascale Lacan², Daniel Spiegel³, Coralie Barrau²

Affiliations

¹ Myopia and Visual Development Lab, College of Nursing and Health Sciences, Caring Futures Institute, Flinders University, Adelaide, South Australia, Australia.
² Essilor International, Centre of Innovation and Technologies Europe, Paris, France.
³ Essilor Asia Pacific Pte Ltd, Singapore City, Singapore, Singapore.

PMID: 39244703
DOI: 10.1111/opo.13390

Abstract

Purpose: Given the potential role of light and its wavelength on ocular growth, this study investigated the effect of short-term exposure to red, cyan and blue light on ocular biometry in humans.

Methods: Forty-four young adults and 20 children, comprising emmetropes and myopes, underwent 2-h sessions of cyan (507 nm), red (638 nm) and broadband white light on three separate days via light-emitting glasses. Additionally, young adults were exposed to blue light (454 nm) on an additional day. Axial length (AL) and choroidal thickness (CT) were measured in the right eye before the light exposure (0 min), after 60 and 120 min of exposure and 30 min after light offset using an optical biometer and optical coherence tomographer, respectively.

Results: Compared to broadband light, exposure to red light resulted in a significant increase in AL (mean difference between white and red light at 120 min, +0.007 mm [0.002]), but no significant change in CT, while cyan light caused a significant AL reduction (-0.010 mm [0.003]) and choroidal thickening (+0.008 mm [0.002]) in young adults (p < 0.05). Blue light caused a significant decrease of -0.007 mm (0.002) in young adult eyes at 60 min (p < 0.05). In children, cyan light led to a significant reduction in AL (-0.016 mm [0.004]) and strong sustained choroidal thickening (+0.014 mm [0.004]) compared to broadband light at 120 min (p < 0.05). The effects of cyan light on AL and CT were found to be stronger in myopic young adults and emmetropic children. The opposing effects of red and cyan light on ocular biometry were similar between the two age groups (p > 0.05).

Conclusions: Exposure to cyan light resulted in AL reduction and choroidal thickening in both young adults and children. Further research is needed to determine the application of these results in developing interventions for myopia control.

Keywords: axial length; choroidal thickness; chromaticity; cyan light; myopia; wavelength.

Abstract

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