Elexacaftor/tezacaftor/ivacaftor's effects on cystic fibrosis infections are maintained, but not increased, after 3.5 years of treatment

J Clin Invest. 2024 Sep 5;134(20):e184171. doi: 10.1172/JCI184171.
No abstract available

Keywords: Bacterial infections; Microbiology.

MeSH terms

  • Adolescent
  • Adult
  • Aminophenols* / therapeutic use
  • Benzodioxoles* / therapeutic use
  • Child
  • Cystic Fibrosis Transmembrane Conductance Regulator
  • Cystic Fibrosis* / drug therapy
  • Cystic Fibrosis* / genetics
  • Drug Combinations*
  • Female
  • Humans
  • Indoles* / therapeutic use
  • Male
  • Pseudomonas Infections / drug therapy
  • Pseudomonas Infections / microbiology
  • Pyrazoles* / therapeutic use
  • Pyridines / therapeutic use
  • Pyrroles / therapeutic use
  • Pyrrolidines
  • Quinolines
  • Quinolones* / therapeutic use

Substances

  • Benzodioxoles
  • Aminophenols
  • Indoles
  • Quinolones
  • Pyrazoles
  • Drug Combinations
  • ivacaftor
  • elexacaftor
  • Pyridines
  • Pyrroles
  • tezacaftor
  • elexacaftor, ivacaftor, tezacaftor drug combination
  • CFTR protein, human
  • Pyrrolidines
  • Quinolines
  • Cystic Fibrosis Transmembrane Conductance Regulator