Next generation probiotics for human health: An emerging perspective

Tawseefa Jan; Rajeshwari Negi; Babita Sharma; Sanjeev Kumar; Sangram Singh; Ashutosh Kumar Rai; Sheikh Shreaz; Sarvesh Rustagi; Nisha Chaudhary; Tanvir Kaur; Divjot Kour; Mohd Aaqib Sheikh; Krishan Kumar; Ajar Nath Yadav; Naseer Ahmed

doi:10.1016/j.heliyon.2024.e35980

Next generation probiotics for human health: An emerging perspective

Heliyon. 2024 Aug 12;10(16):e35980. doi: 10.1016/j.heliyon.2024.e35980. eCollection 2024 Aug 30.

Authors

Tawseefa Jan¹, Rajeshwari Negi², Babita Sharma³, Sanjeev Kumar⁴, Sangram Singh⁵, Ashutosh Kumar Rai⁶, Sheikh Shreaz⁷, Sarvesh Rustagi⁸, Nisha Chaudhary⁹, Tanvir Kaur², Divjot Kour³, Mohd Aaqib Sheikh¹, Krishan Kumar¹⁰, Ajar Nath Yadav^{2

11

12}, Naseer Ahmed¹

Affiliations

¹ Department of Food Technology, Dr. Khem Singh Gill Akal College of Agriculture, Eternal University, Baru Sahib, Sirmaur, Himachal Pradesh, India.
² Department of Genetics, Plant Breeding and Biotechnology, Dr. Khem Singh Gill Akal College of Agriculture, Eternal University, Baru Sahib, Sirmaur, Himachal Pradesh, India.
³ Department of Microbiology, Akal College of Basic Science, Eternal University, Baru Sahib, Sirmaur, Himachal Pradesh, India.
⁴ Faculty of Agricultural Sciences, GLA University, Mathura, Uttar Pradesh, India.
⁵ Department of Biochemistry, Dr. Ram Manohar Lohia Avadh University, Ayodhya, Uttar Pradesh, India.
⁶ Department of Biochemistry, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Kingdom of Saudi Arabia.
⁷ Desert Agriculture and Ecosystem Department, Environment and Life Sciences Research Center, Kuwait Institute for Scientific Research, Safat, Kuwait.
⁸ Depratment of Food Technology, School of Applied and Life Sciences, Uttaranchal University, Dehradun, Uttarakhand, India.
⁹ Depratment of Food Science and Technology, Agriculture University, Jodhpur, Rajasthan, India.
¹⁰ Department of Food Technology, Rajiv Gandhi University, Doimukh, Arunachal Pradesh, India.
¹¹ Centre of Research Impact and Outcome, Chitkara University, Rajpura, Punjab, India.
¹² Chitkara Center for Research and Development, Chitkara University, Himachal Pradesh, India.

Abstract

Over recent years, the scientific community has acknowledged the crucial role of certain microbial strains inhabiting the intestinal ecosystem in promoting human health, and participating in various beneficial functions for the host. These microorganisms are now referred to as next-generation probiotics and are currently considered as biotherapeutic products and food or nutraceutical supplements. However, the majority of next-generation probiotic candidates pose nutritional demands and exhibit high sensitivity towards aerobic conditions, leading to numerous technological hurdles in large-scale production. This underscores the need for the development of suitable delivery systems capable of enhancing the viability and functionality of these probiotic strains. Currently, potential candidates for next generation probiotics (NGP) are being sought among gut bacteria linked to health, which include strains from the genera Bacteroids, Faecalibacterium, Akkermansia and Clostridium. In contrast to Lactobacillus spp. and Bifidobacterium spp., NGP, particularly Bacteroids spp. and Clostridium spp., appear to exhibit greater ambiguity regarding their potential to induce infectious diseases. The present review provides a comprehensive overview of NGPs in terms of their health beneficial effects, regulation framework and risk assessment targeting relevant criteria for commercialization in food and pharmaceutical markets.

Keywords: Clinical trials; Gut microbiota; Live biotherapeutics; Next generation probiotics; Synbiotics.

Publication types

Review